000148837 001__ 148837
000148837 005__ 20250122151649.0
000148837 0247_ $$2doi$$a10.1016/j.euroneuro.2024.12.002
000148837 0248_ $$2sideral$$a142052
000148837 037__ $$aART-2025-142052
000148837 041__ $$aeng
000148837 100__ $$aGil-Berrozpe, Gustavo J.
000148837 245__ $$aInterrelationships between polygenic risk scores, cognition, symptoms, and functioning in first-episode psychosis: A network analysis approach
000148837 260__ $$c2025
000148837 5203_ $$aPsychopathological manifestations and cognitive impairments are core features of psychotic disorders. Polygenic risk scores (PRS) offer insights into the relationships between genetic vulnerability, symptomatology, and cognitive impairments. This study used a network analysis to explore the connections between PRS, cognition, psychopathology, and overall functional outcomes in individuals experiencing a first episode of psychosis (FEP). The study sample comprised 132 patients with FEP. Genetic data were used to construct PRS for mental disorders and cognitive traits via PRS-continuous shrinkage. We conducted comprehensive clinical and neuropsychological assessments at 2 months post-diagnosis and again at a 2-year follow-up. A network analysis was performed to generate two distinct networks and their centrality indices, encompassing 19 variables across domains such as symptoms, cognition, functioning, and PRS. Variables were grouped within related domains, and stronger relationships were observed within domains than between them. PRS for schizophrenia showed weak negative associations with attention, working memory, and verbal memory, while PRS for cognitive performance showed weak positive associations with attention. Negative symptoms were negatively associated with functioning and verbal memory at both the 2-month and 2-year assessments, as well as with social cognition at 2 years. Poor functioning was moderately related to greater severity of Positive and Negative Syndrome Scale dimensions. This study identified pathways linking PRS, cognition, symptoms, and functioning, suggesting that genetic risk may serve as a marker of vulnerability and disorder progression. The findings also highlight the importance of considering genetic predispositions alongside clinical and cognitive factors to better understand the heterogeneity of psychotic disorders.
000148837 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CP21-00059$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-02148$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI19-00766$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI19-01698$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00473$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI22-01985$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0009-0025
000148837 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148837 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148837 700__ $$aSegura, Alex G.
000148837 700__ $$aSánchez-Torres, Ana M.
000148837 700__ $$aAmoretti, Silvia
000148837 700__ $$aGiné-Servén, Eloi
000148837 700__ $$aVieta, Eduard
000148837 700__ $$aMezquida, Gisela
000148837 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, Antonio$$uUniversidad de Zaragoza
000148837 700__ $$aGonzalez-Pinto, Ana
000148837 700__ $$aAndreu-Bernabeu, Alvaro
000148837 700__ $$aRoldán, Alexandra
000148837 700__ $$aForte, Maria Florencia
000148837 700__ $$aCastro, Josefina
000148837 700__ $$aBergé, Daniel
000148837 700__ $$aRodríguez, Natalia
000148837 700__ $$aBallesteros, Alejandro
000148837 700__ $$aMas, Sergi
000148837 700__ $$aCuesta, Manuel J.
000148837 700__ $$aBernardo, Miquel
000148837 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000148837 773__ $$g92 (2025), 52-61$$pEur. neuropsychopharmacol.$$tEUROPEAN NEUROPSYCHOPHARMACOLOGY$$x0924-977X
000148837 8564_ $$s1173319$$uhttps://zaguan.unizar.es/record/148837/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2025-12-24
000148837 8564_ $$s2451253$$uhttps://zaguan.unizar.es/record/148837/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2025-12-24
000148837 909CO $$ooai:zaguan.unizar.es:148837$$particulos$$pdriver
000148837 951__ $$a2025-01-22-14:46:14
000148837 980__ $$aARTICLE