Universidad de Zaragoza Repository

000148861 001__ 148861
000148861 005__ 20250923084444.0
000148861 0247_ $$2doi$$a10.3390/jcm13237198
000148861 0248_ $$2sideral$$a142060
000148861 037__ $$aART-2024-142060
000148861 041__ $$aeng
000148861 100__ $$aMoreno-Juste, Aída
000148861 245__ $$aMultimorbidity in Patients with Chronic Liver Disease: A Population-Based Study in the EpiChron Cohort, Spain
000148861 260__ $$c2024
000148861 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148861 5203_ $$aBackground/Objectives: Chronic liver disease (CLD) is highly relevant in clinical practice due to its increasing incidence and associated mortality. We aimed to exhaustively characterize the multimorbidity of patients with CLD. Methods: This is a retrospective observational study of patients aged 18 years and older with a diagnosis of CLD in 2015 in the EpiChron Cohort (Spain). We analyzed the prevalence of comorbidities according to sex and age, conducted a logistic regression analysis with CLD as the independent variable and each of the comorbidities as dependent variables to obtain odds ratios (OR) adjusted for age and sex, and performed an exploratory factor analysis to identify the presence of multimorbidity patterns. Results: A total of 6836 adults had a diagnosis of CLD (mean age 61.6 years; 62.5% women), with an average of 13 co-existing chronic conditions. Arterial hypertension, lipid metabolism disorders, diabetes, obesity, and musculoskeletal diseases were the most frequent diseases. From the list of 110 chronic conditions analyzed, 75 were systematically associated with CLD, including (OR, 95% confidence interval) chronic pancreatitis (41.2, 33.5–50.6) and inherited metabolic disorders (14.9, 11.8–18.8). Three multimorbidity patterns were identified in both men and women, including cardiovascular, metabolic-geriatric, and mental-substance use, with some differences by sex. Conclusions: Multimorbidity is the norm in patients with CLD. Our results reveal that a comprehensive and integral approach based on person-centered care, which should take into account their entire spectrum of multimorbidity, is necessary during the care of this type of patient in clinical practice.
000148861 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B01-23R$$9info:eu-repo/grantAgreement/ES/ISCIII-RICAPPS/RD21-0016-0019
000148861 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000148861 590__ $$a2.9$$b2024
000148861 592__ $$a0.919$$b2024
000148861 591__ $$aMEDICINE, GENERAL & INTERNAL$$b65 / 332 = 0.196$$c2024$$dQ1$$eT1
000148861 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1
000148861 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148861 700__ $$0(orcid)0000-0002-5119-5093$$aPoblador-Plou, Beatriz
000148861 700__ $$aLaguna-Berna, Clara
000148861 700__ $$aCruces-Mateo, Belén
000148861 700__ $$aLenotti, Elisa
000148861 700__ $$aSantos-Mejías, Alejandro
000148861 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno-Feliú, Luis A.$$uUniversidad de Zaragoza
000148861 700__ $$0(orcid)0000-0002-5440-1710$$aGimeno-Miguel, Antonio
000148861 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000148861 773__ $$g13, 23 (2024), 7198 [15 pp.]$$pJ. clin.med.$$tJournal of Clinical Medicine$$x2077-0383
000148861 8564_ $$s1141728$$uhttps://zaguan.unizar.es/record/148861/files/texto_completo.pdf$$yVersión publicada
000148861 8564_ $$s2794485$$uhttps://zaguan.unizar.es/record/148861/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148861 909CO $$ooai:zaguan.unizar.es:148861$$particulos$$pdriver
000148861 951__ $$a2025-09-22-14:52:43
000148861 980__ $$aARTICLE

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