000148871 001__ 148871 000148871 005__ 20250122151649.0 000148871 0247_ $$2doi$$a10.1016/j.livsci.2024.105628 000148871 0248_ $$2sideral$$a142057 000148871 037__ $$aART-2024-142057 000148871 041__ $$aeng 000148871 100__ $$aBottegal, Diego Nicolas 000148871 245__ $$aMild synergistic effects of a dietary source of polyphenols (Ceratonia siliqua L.) and vitamin E on light lambs’ rumination activity, nutritional status, and gastrointestinal redox-immune markers 000148871 260__ $$c2024 000148871 5060_ $$aAccess copy available to the general public$$fUnrestricted 000148871 5203_ $$aThis study aimed to evaluate the effect of dietary inclusion of carob pulp (0 vs. 20 % Cp, Ceratonia siliqua L.) and vitamin E (Vit E, 40 vs. 300 IU/kg of concentrate) on growth performance, time-budget and eating behaviour, blood metabolites, gastrointestinal and immune markers of fattening light lambs. Seventy-two weaned lambs (females and entire males) were randomly allocated in 12 group pens (6 animals/pen) in a 2 × 2 nutritional factorial design. Growth performance was evaluated, and blood samples were collected twice, whereas behaviour and eating pattern were recorded three times in the fattening period. Gene expression was evaluated by collecting ruminal, jejunal and ileal tissue samples at slaughter. The Cp inclusion did not affect lambs’ performance, but the High Vit E improved the lambs’ growth. Likewise, both Cp and High Vit E independently increased the haematocrit value while only High Vit E improved the plasma α-tocopherol concentration and decreased the ratio MDA: α-tocopherol, considered a proxy of enhanced redox balance. Providing simultaneously 20 % of Cp and High Vit E boosted rumination activity. Dietary Cp modified the eating pattern which was slightly delayed to the early afternoon, and decreased blood lactate. In the jejunum, High Vit E and 20 %-Cp diets down-regulated IFN-γ expression, while High Vit E down-regulated TNF-α expression. In the ileum, Cp decreased the expression of GPX2, whereas High Vit E down-regulated TGF-β and up-regulated CAT expression. Mild synergistic effects of dietary Cp and Vit E were evident on the nutritional status and gastrointestinal redox-immune markers of concentrate-fed lambs. 000148871 536__ $$9info:eu-repo/grantAgreement/EC/H2020/801586/EU/International Doctoral Programme for Talent Attraction to the Campus of International Excellence of the Ebro Valley/IberusTalent$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 801586-IberusTalent 000148871 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000148871 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000148871 700__ $$0(orcid)0000-0002-7829-1448$$aLobón, Sandra 000148871 700__ $$aSerrano-Pérez, Beatriz 000148871 700__ $$aMartín-Alonso, María José 000148871 700__ $$0(orcid)0000-0002-3005-2675$$aLatorre, María Ángeles$$uUniversidad de Zaragoza 000148871 700__ $$0(orcid)0000-0001-6445-849X$$aÁlvarez-Rodríguez, Javier$$uUniversidad de Zaragoza 000148871 7102_ $$12008$$2700$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Producción Animal 000148871 773__ $$g291 (2024), 105628 [12 pp.]$$pLivest. Sci.$$tLivestock Science$$x1871-1413 000148871 8564_ $$s1881673$$uhttps://zaguan.unizar.es/record/148871/files/texto_completo.pdf$$yVersión publicada 000148871 8564_ $$s2088166$$uhttps://zaguan.unizar.es/record/148871/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000148871 909CO $$ooai:zaguan.unizar.es:148871$$particulos$$pdriver 000148871 951__ $$a2025-01-22-14:46:56 000148871 980__ $$aARTICLE