000148872 001__ 148872
000148872 005__ 20250122151649.0
000148872 0247_ $$2doi$$a10.1002/ajoc.202400443
000148872 0248_ $$2sideral$$a142059
000148872 037__ $$aART-2024-142059
000148872 041__ $$aeng
000148872 100__ $$0(orcid)0000-0002-0904-9180$$aArdevines, Sandra$$uUniversidad de Zaragoza
000148872 245__ $$aMulticomponent Cyanation of 2-Amino-3-cyano-4<i>H</i>-chromenes in Aqueous Media
000148872 260__ $$c2024
000148872 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148872 5203_ $$aChromenes represent a pivotal molecular structure found in a diverse range of biologically active compounds. Specifically, derivatives of 2‐amino‐3‐cyano‐4H‐chromene have demonstrated pharmacological applications, displaying potential antioxidant and anticancer activities. This has heightened interest in the exploration of new and more efficient methods for their synthesis. In recent years, few examples have emerged, focusing on the organocatalytic and enantioselective synthesis of 2‐amino‐3‐cyano‐4H‐chromene derivatives, although the overall number of works to date is limited. In this study, we present the results of the synthesis of 2‐amino‐4H‐chromen‐3,4‐dicarbonitriles through a Michael addition of cyanide to 2‐iminochromenes. To achieve this, we utilized a mild source of cyanide (acetone cyanohydrin), green solvents and catalytic conditions at room temperature, via a multicomponent approach. Furthermore, we initiated the enantioselective study of this process using chiral organocatalysts obtaining promising preliminary results.
000148872 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2020-117455GB-I00$$9info:eu-repo/grantAgreement/ES/DGA/E07-23R
000148872 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000148872 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148872 700__ $$aGarcés-Marín, Miryam
000148872 700__ $$aCervantes-Cerrada, Paula
000148872 700__ $$aAAmir, Subhan
000148872 700__ $$0(orcid)0000-0002-5244-9569$$aHerrera, Raquel P.
000148872 700__ $$0(orcid)0000-0001-6832-8983$$aMarqués-López, Eugenia$$uUniversidad de Zaragoza
000148872 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000148872 773__ $$g13, 12 (2024), e202400443 [6 pp.]$$pAsian j. org. chem.$$tAsian journal of organic chemistry$$x2193-5807
000148872 8564_ $$s3343412$$uhttps://zaguan.unizar.es/record/148872/files/texto_completo.pdf$$yVersión publicada
000148872 8564_ $$s2911559$$uhttps://zaguan.unizar.es/record/148872/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148872 909CO $$ooai:zaguan.unizar.es:148872$$particulos$$pdriver
000148872 951__ $$a2025-01-22-14:46:57
000148872 980__ $$aARTICLE