000148920 001__ 148920
000148920 005__ 20250123152145.0
000148920 0247_ $$2doi$$a10.1111/febs.12466
000148920 0248_ $$2sideral$$a128545
000148920 037__ $$aART-2013-128545
000148920 041__ $$aeng
000148920 100__ $$0(orcid)0000-0002-6600-1618$$aMoreno-Loshuertos, Raquel$$uUniversidad de Zaragoza
000148920 245__ $$aLength variation in the mouse mitochondrial tRNAArg DHU loop size promotes oxidative phosphorylation functional differences
000148920 260__ $$c2013
000148920 5203_ $$aThe efficiency of the cellular oxidative phosphorylation system was recently shown to be modulated by common mitochondrial tRNA(A) (rg) haplotypes. The molecular mechanism by which some mt-Tr haplotypes induce these functional differences remains undetermined. Common polymorphisms in mouse mt-Tr genes affect the size of the dihydrouridine loop in the mature tRNA, producing loops of between five and seven nucleotides, the largest being a rare variant among mammals. Here, we analyzed a new mt-Tr variant identified in C3H mice, and found that it is mitochondrial tRNA loop size, but not the specific sequence, that is responsible for the observed differences in cellular respiration. We further found that the sensitivity of mitochondrial protein synthesis to specific inhibitors is dependent on the mt-Tr gene haplotype, and confirmed that the differences in oxidative phosphorylation performance are masked by a reactive oxygen species-induced compensatory increase in mitochondrial biogenesis.
000148920 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B55$$9info:eu-repo/grantAgreement/ES/ISCIII/C03-06-REDCIEN$$9info:eu-repo/grantAgreement/ES/ISCIII/G03-011-ECEMECRE$$9info:eu-repo/grantAgreement/ES/ISCIII/G03-054-REDEMETH$$9info:eu-repo/grantAgreement/ES/ISCIII/PS09-00946$$9info:eu-repo/grantAgreement/ES/MICINN/SAF2003-00103
000148920 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000148920 590__ $$a3.986$$b2013
000148920 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b85 / 290 = 0.293$$c2013$$dQ2$$eT1
000148920 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000148920 700__ $$0(orcid)0000-0002-8705-2799$$aPérez-Martos, Acisclo
000148920 700__ $$0(orcid)0000-0001-8971-7355$$aFernández-Silva, Patricio$$uUniversidad de Zaragoza
000148920 700__ $$0(orcid)0000-0002-4931-6730$$aEnríquez, José Antonio$$uUniversidad de Zaragoza
000148920 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000148920 773__ $$g280, 20 (2013), 4983-4998$$pFEBS J.$$tFEBS Journal$$x1742-464X
000148920 8564_ $$s592272$$uhttps://zaguan.unizar.es/record/148920/files/texto_completo.pdf$$yPostprint
000148920 8564_ $$s2273542$$uhttps://zaguan.unizar.es/record/148920/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000148920 909CO $$ooai:zaguan.unizar.es:148920$$particulos$$pdriver
000148920 951__ $$a2025-01-23-14:47:06
000148920 980__ $$aARTICLE