000148950 001__ 148950
000148950 005__ 20250123152146.0
000148950 0248_ $$2sideral$$a93654
000148950 037__ $$aART-2016-93654
000148950 041__ $$aeng
000148950 100__ $$0(orcid)0000-0002-2557-4890$$aFernández, A.$$uUniversidad de Zaragoza
000148950 245__ $$aRelationship between pro-inflammatory cytokines, IL-10 anti-inflammatory cytokine and serum proteins in healthy lambs and with diarrhea
000148950 260__ $$c2016
000148950 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148950 5203_ $$aWe determined the levels of the cytokines IL-6, IL-1ß, IFN-¿ and IL-10 in fifteen lambs during the first month of life. The correlation between these cytokines and serum protein fractions was studied. In addition, the concentration of these cytokines in fourteen lambs with diarrhea was determined. IFN-? (73.85±121 pg/ml) peaked at day 1, IL-6 (7910±2329 pg/ml) and IL-1ß (5234±2461 pg/ml) peaked at day 4, and IL-10 (63.4±5.2 pg/ml), peaked at day 28. At day 11 the highest correlation between IL-6 and IL-1ß was identified. An increase (P<0.01) in IL-1ß concentration was detected in diarrheic lambs. There was a positive correlation between IL-6, IL-1ß and total protein levels in sick lambs and also between IL-6 and total globulins and IL-1ß and total globulins. These results indicate that with the exception of IL-10, cytokine concentrations in healthy lambs follow time-dependent evolution. The higher concentration of IL-1ß detected in diarrheic lambs could be used as are reliable inflammatory marker in ovine pathology. Further work is required to understand the role of cytokines in both physiological and pathological processes.
000148950 536__ $$9info:eu-repo/grantAgreement/ES/UZ/UZ2010-BIO-04
000148950 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000148950 590__ $$a0.813$$b2016
000148950 591__ $$aVETERINARY SCIENCES$$b75 / 135 = 0.556$$c2016$$dQ3$$eT2
000148950 592__ $$a0.338$$b2016
000148950 593__ $$aVeterinary (miscellaneous)$$c2016$$dQ2
000148950 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148950 700__ $$aMarteles, D.
000148950 700__ $$0(orcid)0000-0002-7655-2472$$aRuiz de Arcaute, M.$$uUniversidad de Zaragoza
000148950 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, D.$$uUniversidad de Zaragoza
000148950 700__ $$0(orcid)0000-0002-9500-4703$$aConde, T.$$uUniversidad de Zaragoza
000148950 700__ $$0(orcid)0000-0002-1934-5397$$aLoste, A.$$uUniversidad de Zaragoza
000148950 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000148950 773__ $$g36, 1 (2016), 63-67$$pPAKISTAN VETERINARY JOURNAL$$tPAKISTAN VETERINARY JOURNAL$$x0253-8318
000148950 85641 $$uhttps://www.pvj.com.pk/abstract/36_1/15-220.htm$$zTexto completo de la revista
000148950 8564_ $$s201725$$uhttps://zaguan.unizar.es/record/148950/files/texto_completo.pdf$$yVersión publicada
000148950 8564_ $$s2777107$$uhttps://zaguan.unizar.es/record/148950/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148950 909CO $$ooai:zaguan.unizar.es:148950$$particulos$$pdriver
000148950 951__ $$a2025-01-23-14:47:43
000148950 980__ $$aARTICLE