000148973 001__ 148973
000148973 005__ 20250123152146.0
000148973 0247_ $$2doi$$a10.1016/j.repc.2022.02.010
000148973 0248_ $$2sideral$$a142092
000148973 037__ $$aART-2023-142092
000148973 041__ $$aeng
000148973 100__ $$aRaposeiras-Roubín, Sergio
000148973 245__ $$aLong-term prognostic impact of beta-blockers in patients with Takotsubo syndrome: Results from the RETAKO Registry
000148973 260__ $$c2023
000148973 5060_ $$aAccess copy available to the general public$$fUnrestricted
000148973 5203_ $$aBackground
No evidence-based therapy has yet been established for Takotsubo syndrome (TTS). Given the putative harmful effects of catecholamines in patients with TTS, beta-blockers may potentially decrease the intensity of the detrimental cardiac effects in those patients.
Objective
The purpose of this study was to assess the impact of beta-blocker therapy on long-term mortality and TTS recurrence.
Methods
The cohort study used the national Spanish Registry on TakoTsubo Syndrome (RETAKO). A total of 970 TTS post-discharge survivors, without pheochromocytoma, left ventricular outflow tract obstruction, sustained ventricular arrhythmias, and significant bradyarrhythmias, between January 1, 2003, and July 31, 2018, were assessed. Cox regression analysis and inverse probability weighting (IPW) propensity score analysis were used to evaluate the association between beta-blocker therapy and survival free of TTS recurrence.
Results
From 970 TTS patients, 582 (60.0%) received beta-blockers. During a mean follow-up of 2.5 ± 3.3 years, there were 87 deaths (3.6 per 100 patients/year) and 29 TTS recurrences (1.2 per 100 patient/year). There was no significant difference in follow-up mortality or TTS recurrence in unadjusted and adjusted Cox analysis (hazard ratio [HR] 0.86, 95% confidence interval [CI] 0.59–1.27, and 0.95, 95% CI 0.57–1.13, respectively). After weighting and adjusting by IPW, differences in one-year survival free of TTS recurrence between patients treated and untreated with beta-blockers were not found (average treatment effect −0.01, 95% CI −0.07 to 0.04; p=0.621).
Conclusions
In this observational nationwide study from Spain, there was no significant association between beta-blocker therapy and follow-up survival free of TTS recurrence.
000148973 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000148973 590__ $$a1.6$$b2023
000148973 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b139 / 222 = 0.626$$c2023$$dQ3$$eT2
000148973 592__ $$a0.333$$b2023
000148973 593__ $$aCardiology and Cardiovascular Medicine$$c2023$$dQ3
000148973 594__ $$a2.7$$b2023
000148973 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000148973 700__ $$aNúñez-Gil, Iván J.
000148973 700__ $$aJamhour, Karim
000148973 700__ $$aAbu-Assi, Emad
000148973 700__ $$aConty, David Aritza
000148973 700__ $$aVedia, Oscar
000148973 700__ $$aAlmendro-Delia, Manuel
000148973 700__ $$aSionis, Alessandro
000148973 700__ $$aMartin-Garcia, Agustin C.
000148973 700__ $$aCorbí-Pascual, Miguel
000148973 700__ $$aMartínez-Sellés, Manuel
000148973 700__ $$aUribarri, Aitor
000148973 700__ $$aGuillén, Marta
000148973 700__ $$aAcuña, José María García
000148973 700__ $$aPaís, Javier Lopez
000148973 700__ $$aBlanco, Emilia
000148973 700__ $$aLinares Vicente, José A.
000148973 700__ $$aFlecha, Alejandro Sánchez Grande
000148973 700__ $$aAndrés, Mireia
000148973 700__ $$aPérez-Castellanos, Alberto
000148973 700__ $$aAlonso, Joaquín
000148973 700__ $$aRosselló, Xavier
000148973 700__ $$aRomo, Andrés Iñiguez
000148973 700__ $$aFeltes, Gisela
000148973 773__ $$g42, 3 (2023), 237-246$$pRevista portuguesa de cardiologia$$tRevista portuguesa de cardiologia$$x0870-2551
000148973 8564_ $$s1753968$$uhttps://zaguan.unizar.es/record/148973/files/texto_completo.pdf$$yVersión publicada
000148973 8564_ $$s2063067$$uhttps://zaguan.unizar.es/record/148973/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000148973 909CO $$ooai:zaguan.unizar.es:148973$$particulos$$pdriver
000148973 951__ $$a2025-01-23-14:48:07
000148973 980__ $$aARTICLE