000149028 001__ 149028
000149028 005__ 20250124153131.0
000149028 0247_ $$2doi$$a10.1038/s41598-023-30281-z
000149028 0248_ $$2sideral$$a142156
000149028 037__ $$aART-2023-142156
000149028 041__ $$aeng
000149028 100__ $$aRodrígez, José Manuel Rial
000149028 245__ $$aAdult height and health-related quality of life in patients born small for gestational age treated with recombinant growth hormone
000149028 260__ $$c2023
000149028 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149028 5203_ $$aHealth related quality of life (HRQoL) is a relevant result when assessing the course of different pathologies and the efficacy of their treatments. HRQoL has been studied previously on adults born small for gestational age (SGA), both in the general population and in patients who had received recombinant human growth hormone (rhGH) treatment, with disparate results. Our study included 50 adults who had received rhGH treatment for the SGA indication in 4 Spanish hospitals. Data have been gathered retrospectively from their clinical records, current weight and height were measured, and patients have been asked to fill out SF-36 and QoLAGHDA quality of life forms, and the Graffar test to evaluate their socio-economical status. Patient’s adult height was – 1.2 ± 0.9 SD, lower than their target height of 1 ± 0.8 SD, but gaining 1.7 ± 1 SD from the beginning of the treatment. SF-36 test results showed lower scoring on Mental Health domains than on those related to Physical Health. No correlation was found between HRQoL results and final height, rhGH treatment duration or puberty. Correlation was indeed found between QoLAGHDA and several domains of SF-36, but QoLAGHDA detected fewer patients with low HRQoL than SF-36. Thus, it is concluded that SGA patient’s follow-up should include a HRQoL, neuro-cognitive and psychiatric assessment in their transition to adult age. Adult SGA patients without catch up growth have impaired HRQoL, especially in mental health domains.
000149028 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000149028 590__ $$a3.8$$b2023
000149028 591__ $$aMULTIDISCIPLINARY SCIENCES$$b25 / 134 = 0.187$$c2023$$dQ1$$eT1
000149028 592__ $$a0.9$$b2023
000149028 593__ $$aMultidisciplinary$$c2023$$dQ1
000149028 594__ $$a7.5$$b2023
000149028 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149028 700__ $$aToda, Lourdes Ibañez
000149028 700__ $$aLópez, Ignacio Díez
000149028 700__ $$aMuñoz, Jordi Bosch
000149028 700__ $$aFresno, Luis Salamanca
000149028 700__ $$aHernández, Eugenio Fernández
000149028 700__ $$0(orcid)0000-0002-2865-5813$$ade Arriba Muñoz, Antonio$$uUniversidad de Zaragoza
000149028 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000149028 773__ $$g13, 1 (2023), 1-7$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000149028 8564_ $$s987314$$uhttps://zaguan.unizar.es/record/149028/files/texto_completo.pdf$$yVersión publicada
000149028 8564_ $$s2504140$$uhttps://zaguan.unizar.es/record/149028/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149028 909CO $$ooai:zaguan.unizar.es:149028$$particulos$$pdriver
000149028 951__ $$a2025-01-24-14:49:17
000149028 980__ $$aARTICLE