000149155 001__ 149155
000149155 005__ 20250126114555.0
000149155 0247_ $$2doi$$a10.4103/1673-5374.320990
000149155 0248_ $$2sideral$$a125452
000149155 037__ $$aART-2022-125452
000149155 041__ $$aeng
000149155 100__ $$0(orcid)0000-0003-2656-6750$$aFuentes-Broto, Lorena$$uUniversidad de Zaragoza
000149155 245__ $$aSystemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat
000149155 260__ $$c2022
000149155 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149155 5203_ $$aRetinitis pigmentosa (RP) is a group of inherited retinal disorders that lead to photoreceptor loss. RP has been reported to be related to oxidative stress, autophagy, and inflammation. (-)-Epigallocatechin gallate (EGCG), the most abundant catechin-based flavonoid in green tea leaves, has significant antioxidant, anti-carcinogenic, antimicrobial, and neuroprotective properties. EGCG, given its low molecular weight and hydrophilic properties, can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens, cornea, and retina. EGCG has been shown to provide retinal protection against ischemia; sodium nitroprusside-, N-methyl-D-aspartate-, lipopolysaccharide-, light-, sodium iodate-, or H<inf>2</inf>O<inf>2</inf>-induced damage and diabetic retinopathy. This suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as RP. The aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23H line 1, the model of RP. Albino P23H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of RP. Pigmented P23H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans rats. Rats treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23H rats treated with vehicle. EGCG reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase activities. No differences were observed in visual acuity, nitrate levels, nitrite levels or glutathione S-transferase activity. In conclusion, EGCG not only reduced the loss of visual function in P23H rats but also improved the levels of antioxidant enzymes and reduced oxidative damage. This study was approved by the Institutional Animal Care and Use Committee (CEICA) from the University of Zaragoza under project license PI12/14 on July 11, 2014.
000149155 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-sa$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/es/
000149155 590__ $$a6.1$$b2022
000149155 591__ $$aNEUROSCIENCES$$b42 / 272 = 0.154$$c2022$$dQ1$$eT1
000149155 591__ $$aCELL BIOLOGY$$b58 / 191 = 0.304$$c2022$$dQ2$$eT1
000149155 592__ $$a0.837$$b2022
000149155 593__ $$aDevelopmental Neuroscience$$c2022$$dQ2
000149155 594__ $$a7.4$$b2022
000149155 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149155 700__ $$aPerdices, Lorena
000149155 700__ $$0(orcid)0000-0002-9250-9060$$aSegura, Francisco$$uUniversidad de Zaragoza
000149155 700__ $$aCavero, Ana
000149155 700__ $$aOrduna-Hospital, Elvira
000149155 700__ $$aInsa-Sánchez, Gema$$uUniversidad de Zaragoza
000149155 700__ $$0(orcid)0000-0002-5621-1937$$aSánchez-Cano, AnaIsabel$$uUniversidad de Zaragoza
000149155 700__ $$aFernández-Sánchez, Laura
000149155 700__ $$aCuenca, Nicolás
000149155 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000149155 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000149155 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000149155 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000149155 773__ $$g17, 3 (2022), 625$$pNEURAL REGENERATION RESEARCH$$tNEURAL REGENERATION RESEARCH$$x1673-5374
000149155 8564_ $$s705259$$uhttps://zaguan.unizar.es/record/149155/files/texto_completo.pdf$$yVersión publicada
000149155 8564_ $$s2604450$$uhttps://zaguan.unizar.es/record/149155/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149155 909CO $$ooai:zaguan.unizar.es:149155$$particulos$$pdriver
000149155 951__ $$a2025-01-26-10:47:37
000149155 980__ $$aARTICLE