000149757 001__ 149757
000149757 005__ 20250127155744.0
000149757 0247_ $$2doi$$a10.1016/j.fct.2018.01.044
000149757 0248_ $$2sideral$$a104563
000149757 037__ $$aART-2018-104563
000149757 041__ $$aeng
000149757 100__ $$0(orcid)0000-0003-2685-5739$$aNerin, C.$$uUniversidad de Zaragoza
000149757 245__ $$aA common surfactant used in food packaging found to be toxic for reproduction in mammals
000149757 260__ $$c2018
000149757 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149757 5203_ $$aMigration from a multilayer plastic material intended for food contact showed that 2, 4, 7, 9-tetramethyl-5-decyne-4, 7-diol mixture (surfynol), used as a surfactant in the adhesive employed to build the multilayer, was transferred to water and other food simulants in contact with the plastic. When these multilayer plastics were used for containing seminal doses for artificial insemination, it was found that fertility was seriously damaged in terms of motility, acrosome integrity, mitochondrial activity and penetration capacity in the cells, thus affecting male fertility. Quantitative proteomic analysis of exposed germinal cells demonstrated the inhibition of key proteins involved in the fertilization capacity by affecting the cytoskeleton, sperm motility, the energy machinery and sperm defense mechanisms against oxidation, therefore confirming the surfactant-induced male infertility. These results open up new and interesting perspectives for the study of reprotoxicity caused by different chemicals common in our daily lives. Significance: This paper demonstrates the toxicity for reproduction of a common surfactant used in food packaging and the scientific reasons why the sperm loses reproductive capacity in presence of this chemical. So, the surfactant affects the male fertility. The surfactant is present in many adhesives used either for building multilayer materials or to glue paper and plastic in food packaging. This is the first time that reprotoxicity is demonstrated for this compound. According to the theoretical approach Threshold of Toxicological Concern (TTC) the compound is highly toxic but experimental data did not exist so far. The study described in this paper and the results obtained open a door to further research in which male infertility caused by chemicals could be demonstrated.
000149757 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T10$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2014-55711-R$$9info:eu-repo/grantAgreement/ES/MINECO/IPT-2012-0261-420000
000149757 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000149757 590__ $$a3.775$$b2018
000149757 591__ $$aTOXICOLOGY$$b18 / 93 = 0.194$$c2018$$dQ1$$eT1
000149757 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b21 / 135 = 0.156$$c2018$$dQ1$$eT1
000149757 592__ $$a0.916$$b2018
000149757 593__ $$aFood Science$$c2018$$dQ1
000149757 593__ $$aToxicology$$c2018$$dQ1
000149757 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000149757 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000149757 700__ $$0(orcid)0000-0003-2638-9221$$aCanellas, E.
000149757 700__ $$0(orcid)0000-0002-8765-4319$$aVera, P.$$uUniversidad de Zaragoza
000149757 700__ $$aGarcia-Calvo, E.
000149757 700__ $$aLuque-Garcia, J.L.
000149757 700__ $$aCámara, C.
000149757 700__ $$aAusejo, R.
000149757 700__ $$aMiguel, J.
000149757 700__ $$aMendoza, N.
000149757 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000149757 7102_ $$12009$$2X$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cProy. investigación HVA
000149757 773__ $$g113 (2018), 115-124$$pFood chem. toxicol.$$tFOOD AND CHEMICAL TOXICOLOGY$$x0278-6915
000149757 8564_ $$s562401$$uhttps://zaguan.unizar.es/record/149757/files/texto_completo.pdf$$yPostprint
000149757 8564_ $$s2055472$$uhttps://zaguan.unizar.es/record/149757/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000149757 909CO $$ooai:zaguan.unizar.es:149757$$particulos$$pdriver
000149757 951__ $$a2025-01-27-14:42:42
000149757 980__ $$aARTICLE