doi:10.1002/chem.201204197engTejedor, R.M.Uriel, S.Graus, S.Sierra, T.Serrano, J.L.Claramunt, R.M.López, C.Pérez-Torralba, M.Alkorta, I.Elguero, J.A facile method to determine the absolute structure of achiral molecules: Supramolecular-tilt structuresART-2013-81877Achiral compounds 4-methoxy-4-(p-methoxyphenyl)cyclohexanoneethylene ketal (2), 4-hydroxy-4-(p-methoxy phenyl)cyclohexanoneethylene ketal (3), and 3,5-dimethyl-4-nitropyrazole (4) crystallized in chiral structures and the samples showed an enantiomeric excess. We have determined the absolute structures of these compounds by using X-ray diffraction with copper radiation at low temperatures. Moreover, we have also established the prevalent absolute structures in these samples, by comparing their calculated and solid-state vibrational circular dichroism (VCD) spectra. The consistency of this method was confirmed by using (R,R)-2,8-diiodo-4,10-dimethyl-6 H,12H-5,11-methano-dibenzo[b,f][1,5]diazocine, Tröger′s base, (R,R)-1, as a chiral compound of known absolute configuration.2013http://zaguan.unizar.es/record/14979810.1002/chem.201204197http://zaguan.unizar.es/record/149798oai:zaguan.unizar.es:149798info:eu-repo/grantAgreement/ES/CICYT/CTQ2010-16122info:eu-repo/grantAgreement/ES/CICYT/MAT2009-1463-C03-01info:eu-repo/grantAgreement/ES/CICYT/MAT2011-27978-C02-01Chemistry - A European Journal 19, 19 (2013), 6044-6051All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess