000149836 001__ 149836
000149836 005__ 20250210083427.0
000149836 0247_ $$2doi$$a10.1016/j.biomaterials.2013.09.083
000149836 0248_ $$2sideral$$a89073
000149836 037__ $$aART-2014-89073
000149836 041__ $$aeng
000149836 100__ $$aAraña, M.
000149836 245__ $$aEpicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction
000149836 260__ $$c2014
000149836 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149836 5203_ $$aAlthough transplantation of adipose-derived stem cells (ADSC) in chronic myocardial infarction (MI) models is associated with functional improvement, its therapeutic value is limited due to poor long-term cell engraftment and survival. Thus, the objective of this study was to examine whether transplantation of collagen patches seeded with ADSC could enhance cell engraftment and improve cardiac function in models of chronic MI. With that purpose, chronically infarcted Sprague–Dawley rats (n = 58) were divided into four groups and transplanted with media, collagen scaffold (CS), rat ADSC, or CS seeded with rat ADSC (CS-rADSC). Cell engraftment, histological changes, and cardiac function were assessed 4 months after transplantation. In addition, Göttingen minipigs (n = 18) were subjected to MI and then transplanted 2 months later with CS or CS seeded with autologous minipig ADSC (CS-pADSC). Functional and histological assessments were performed 3 months post-transplantation. Transplantation of CS-rADSC was associated with increased cell engraftment, significant improvement in cardiac function, myocardial remodeling, and revascularization. Moreover, transplantation of CS-pADSC in the pre-clinical swine model improved cardiac function and was associated with decreased fibrosis and increased vasculogenesis. In summary, transplantation of CS-ADSC resulted in enhanced cell engraftment and was associated with a significant improvement in cardiac function and myocardial remodeling
000149836 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CP09-00333$$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-01621$$9info:eu-repo/grantAgreement/ES/ISCIII/RD12-0019-0031
000149836 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000149836 590__ $$a8.557$$b2014
000149836 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b1 / 33 = 0.03$$c2014$$dQ1$$eT1
000149836 591__ $$aENGINEERING, BIOMEDICAL$$b2 / 76 = 0.026$$c2014$$dQ1$$eT1
000149836 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000149836 700__ $$aGavira,J . J.
000149836 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000149836 700__ $$aGonzález, A.
000149836 700__ $$aAbizanda, G.
000149836 700__ $$0(orcid)0000-0002-8503-9291$$aCilla, M.
000149836 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, M. M.$$uUniversidad de Zaragoza
000149836 700__ $$aAlbiasu, E.
000149836 700__ $$aAguado, N.
000149836 700__ $$aCasado, M.
000149836 700__ $$aLópez, B.
000149836 700__ $$aGonzález, S.
000149836 700__ $$aSoriano, M.
000149836 700__ $$aMoreno, C.
000149836 700__ $$aMerino, J.
000149836 700__ $$aGarcía-Verdugo, J.
000149836 700__ $$aDíez, J.
000149836 700__ $$0(orcid)0000-0001-8741-6452$$aDoblaré, M.$$uUniversidad de Zaragoza
000149836 700__ $$aPelacho, B.
000149836 700__ $$aProsper, F.
000149836 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000149836 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000149836 773__ $$g35, 1 (2014), 143-151$$pBiomaterials$$tBiomaterials$$x0142-9612
000149836 8564_ $$s6499859$$uhttps://zaguan.unizar.es/record/149836/files/texto_completo.pdf$$yPostprint
000149836 8564_ $$s2390819$$uhttps://zaguan.unizar.es/record/149836/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000149836 909CO $$ooai:zaguan.unizar.es:149836$$particulos$$pdriver
000149836 951__ $$a2025-02-10-08:31:10
000149836 980__ $$aARTICLE