149836 20251017144548.0 doi 10.1016/j.biomaterials.2013.09.083 sideral 89073 ART-2014-89073 eng Araña, M. Epicardial delivery of collagen patches with adipose-derived stem cells in rat and minipig models of chronic myocardial infarction 2014 Access copy available to the general public Unrestricted Although transplantation of adipose-derived stem cells (ADSC) in chronic myocardial infarction (MI) models is associated with functional improvement, its therapeutic value is limited due to poor long-term cell engraftment and survival. Thus, the objective of this study was to examine whether transplantation of collagen patches seeded with ADSC could enhance cell engraftment and improve cardiac function in models of chronic MI. With that purpose, chronically infarcted Sprague–Dawley rats (n = 58) were divided into four groups and transplanted with media, collagen scaffold (CS), rat ADSC, or CS seeded with rat ADSC (CS-rADSC). Cell engraftment, histological changes, and cardiac function were assessed 4 months after transplantation. In addition, Göttingen minipigs (n = 18) were subjected to MI and then transplanted 2 months later with CS or CS seeded with autologous minipig ADSC (CS-pADSC). Functional and histological assessments were performed 3 months post-transplantation. Transplantation of CS-rADSC was associated with increased cell engraftment, significant improvement in cardiac function, myocardial remodeling, and revascularization. Moreover, transplantation of CS-pADSC in the pre-clinical swine model improved cardiac function and was associated with decreased fibrosis and increased vasculogenesis. In summary, transplantation of CS-ADSC resulted in enhanced cell engraftment and was associated with a significant improvement in cardiac function and myocardial remodeling info:eu-repo/grantAgreement/ES/ISCIII/CP09-00333 info:eu-repo/grantAgreement/ES/ISCIII/PI10-01621 info:eu-repo/grantAgreement/ES/ISCIII/RD12-0019-0031 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 8.557 2014 MATERIALS SCIENCE, BIOMATERIALS 1 / 33 = 0.03 2014 Q1 T1 ENGINEERING, BIOMEDICAL 2 / 76 = 0.026 2014 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Gavira,J . J. Peña, E. Universidad de Zaragoza (orcid)0000-0002-0664-5024 González, A. Abizanda, G. Cilla, M. (orcid)0000-0002-8503-9291 Pérez, M. M. Universidad de Zaragoza (orcid)0000-0002-8133-2124 Albiasu, E. Aguado, N. Casado, M. López, B. González, S. Soriano, M. Moreno, C. Merino, J. García-Verdugo, J. Díez, J. Doblaré, M. Universidad de Zaragoza (orcid)0000-0001-8741-6452 Pelacho, B. Prosper, F. 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 35, 1 (2014), 143-151 Biomaterials Biomaterials 0142-9612 6499859 http://zaguan.unizar.es/record/149836/files/texto_completo.pdf Postprint 2390819 http://zaguan.unizar.es/record/149836/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:149836 articulos driver 2025-10-17-14:10:46 ARTICLE