149842 20251017144552.0 doi 10.1098/rsif.2019.0313 sideral 115012 ART-2019-115012 eng Escuer, Javier Universidad de Zaragoza (orcid)0000-0001-7620-3355 Mathematical modelling of the restenosis process after stent implantation 2019 Access copy available to the general public Unrestricted The stenting procedure has evolved to become a highly successful technique for the clinical treatment of advanced atherosclerotic lesions in arteries. However, the development of in-stent restenosis remains a key problem. In this work, a novel two-dimensional continuum mathematical model is proposed to describe the complex restenosis process following the insertion of a stent into a coronary artery. The biological species considered to play a key role in restenosis development are growth factors, matrix metalloproteinases, extracellular matrix, smooth muscle cells and endothelial cells. Diffusion-reaction equations are used for modelling the mass balance between species in the arterial wall. Experimental data from the literature have been used in order to estimate model parameters. Moreover, a sensitivity analysis has been performed to study the impact of varying the parameters of the model on the evolution of the biological species. The results demonstrate that this computational model qualitatively captures the key characteristics of the lesion growth and the healing process within an artery subjected to non-physiological mechanical forces. Our results suggest that the arterial wall response is driven by the damage area, smooth muscle cell proliferation and the collagen turnover among other factors. info:eu-repo/grantAgreement/ES/MINECO/BES-2014-069737 info:eu-repo/grantAgreement/ES/MINECO/DPI2016-76630-C2-1-R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.748 2019 MULTIDISCIPLINARY SCIENCES 18 / 70 = 0.257 2019 Q2 T1 1.694 2019 Biochemistry 2019 Q1 Bioengineering 2019 Q1 Biotechnology 2019 Q1 Biomedical Engineering 2019 Q1 Biophysics 2019 Q1 Biomaterials 2019 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Martínez, Miguel A. Universidad de Zaragoza (orcid)0000-0002-8375-0354 McGinty, Sean Peña, Estefanía Universidad de Zaragoza (orcid)0000-0002-0664-5024 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 16, 157 (2019) J. R. Soc. Interface Journal of the Royal Society Interface 1742-5689 770578 http://zaguan.unizar.es/record/149842/files/texto_completo.pdf Postprint 1383199 http://zaguan.unizar.es/record/149842/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:149842 articulos driver 2025-10-17-14:12:07 ARTICLE