000149869 001__ 149869
000149869 005__ 20250128160611.0
000149869 0247_ $$2doi$$a10.3389/fbioe.2021.690685
000149869 0248_ $$2sideral$$a126892
000149869 037__ $$aART-2021-126892
000149869 041__ $$aeng
000149869 100__ $$0(orcid)0000-0002-2360-8276$$aHernández-López P.$$uUniversidad de Zaragoza
000149869 245__ $$aEffects of the Haemodynamic Stimulus on the Location of Carotid Plaques Based on a Patient-Specific Mechanobiological Plaque Atheroma Formation Model
000149869 260__ $$c2021
000149869 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149869 5203_ $$aIn this work, we propose a mechanobiological atheroma growth model modulated by a new haemodynamic stimulus. To test this model, we analyse the development of atheroma plaques in patient-specific bifurcations of carotid arteries for a total time of 30 years. In particular, eight geometries (left or right carotid arteries) were segmented from clinical images and compared with the solutions obtained computationally to validate the model. The influence of some haemodynamical stimuli on the location and size of plaques is also studied. Plaques predicted by the mechanobiological models using the time average wall shear stress (TAWSS), the oscillatory shear index (OSI) and a new index proposed in this work are compared. The new index predicts the shape index of the endothelial cells as a combination of TAWSS and OSI values and was fitted using data from the literature. The mechanobiological model represents an evolution of the one previously proposed by the authors. This model uses Navier-Stokes equations to simulate blood flow along the lumen in the transient mode. It also employs Darcy''s law and Kedem-Katchalsky equations for plasma and substance flow across the endothelium using the three-pore model. The mass balances of all the substances that have been considered in the model are implemented by convection-diffusion-reaction equations, and finally the growth of the plaques has been computed. The results show that by using the new mechanical stimulus proposed in this study, prediction of plaques is, in most cases, better than only using TAWSS or OSI with a minimal and maximal errors on stenosis ratio of 2.77 and 32.89 %, respectively. However, there are a few geometries in which haemodynamics cannot predict the location of plaques, and other biological or genetic factors would be more relevant than haemodynamics. In particular, the model predicts correctly eleven of the fourteen plaques presented in all the geometries considered. Additionally, a healthy geometry has been computed to check that plaque is not developed with the model in this case. © Copyright © 2021 Hernández-López, Cilla, Martínez and Peña.
000149869 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000149869 590__ $$a6.064$$b2021
000149869 591__ $$aMULTIDISCIPLINARY SCIENCES$$b16 / 74 = 0.216$$c2021$$dQ1$$eT1
000149869 592__ $$a0.925$$b2021
000149869 593__ $$aBioengineering$$c2021$$dQ1
000149869 593__ $$aBiotechnology$$c2021$$dQ1
000149869 593__ $$aBiomedical Engineering$$c2021$$dQ1
000149869 594__ $$a5.4$$b2021
000149869 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149869 700__ $$0(orcid)0000-0002-8503-9291$$aCilla M.
000149869 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez M.$$uUniversidad de Zaragoza
000149869 700__ $$0(orcid)0000-0002-0664-5024$$aPeña E.$$uUniversidad de Zaragoza
000149869 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000149869 773__ $$g9 (2021), 690685 [19 pp]$$pFront. Bioeng. Biotechnol.$$tFrontiers in Bioengineering and Biotechnology$$x2296-4185
000149869 8564_ $$s2771548$$uhttps://zaguan.unizar.es/record/149869/files/texto_completo.pdf$$yVersión publicada
000149869 8564_ $$s2373432$$uhttps://zaguan.unizar.es/record/149869/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149869 909CO $$ooai:zaguan.unizar.es:149869$$particulos$$pdriver
000149869 951__ $$a2025-01-28-14:57:38
000149869 980__ $$aARTICLE