000149883 001__ 149883
000149883 005__ 20251017144634.0
000149883 0247_ $$2doi$$a10.1038/s41366-022-01230-z
000149883 0248_ $$2sideral$$a130593
000149883 037__ $$aART-2023-130593
000149883 041__ $$aeng
000149883 100__ $$aLázaro, J.
000149883 245__ $$aEffect of positive pressure ventilation and bariatric surgery on extracellular vesicle microRNAs in patients with severe obesity and obstructive sleep apnea
000149883 260__ $$c2023
000149883 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149883 5203_ $$aIntroduction
Obstructive sleep apnea (OSA) and severe obesity share a common pathophysiological phenomenon, systemic and tissue hypoxia. Hypoxaemia modifies microRNA expression, particularly, extracellular vesicles microRNAs which are involved in the progression of cardiovascular diseases, metabolic syndrome and cancer. We aim to evaluate extracellular vesicle miRNAs among patients with severe obesity with and without OSA and the effect of OSA and severe obesity treatment: continuous positive airway pressure (CPAP) and bariatric surgery.
Methods
Patients were selected from the Epigenetics Modification in Morbid Obesity and Obstructive Sleep Apnea (EPIMOOSA) study (NCT03995836), a prospective observational study of patients undergoing bariatric surgery. Patients were divided into OSA (Apnea-hyponea index (AHI) > 10) and non-OSA (AHI < 10). Patients with OSA were treated with CPAP for 6 months. Then, all patients had bariatric surgery and re-evaluated 12 months later. At each visit, blood samples were obtained for biobanking. Subsequently, extracellular vesicles were extracted, and then, miRNA expression was analysed.
Results
15 patients with OSA and 9 without OSA completed the protocol. At baseline, patients with OSA showed higher miR16, miR126 and miR320 (p < 0.05) and lower miR223 expression (p < 0.05) than those without OSA. In patients with severe obesity and OSA, after 6 months with CPAP, we observed a significant decrease in miR21 (p < 0.01), miR126 (p < 0.001) and miR320 (p < 0.001), with no changes in any miRNA in patients without OSA. No changes were detected in any miRNA after 6 months of bariatric surgery in patients with or without OSA.
Conclusion
Co-existance of OSA and severe obesity alters the profile of extracellular vesicle miRNAs. Bariatric surgery and weight loss did not reverse this effect meanwhile the treatment with CPAP in patients with severe obesity and OSA showed a recovery outcome in those extracellular vesicle miRNAs. Those facts remark the need for OSA screening in patients with severe obesity.
000149883 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI18-01524$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01940$$9info:eu-repo/grantAgreement/ES/ISCIII/PI21-01954
000149883 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000149883 590__ $$a4.2$$b2023
000149883 591__ $$aNUTRITION & DIETETICS$$b27 / 114 = 0.237$$c2023$$dQ1$$eT1
000149883 591__ $$aENDOCRINOLOGY & METABOLISM$$b40 / 186 = 0.215$$c2023$$dQ1$$eT1
000149883 592__ $$a1.504$$b2023
000149883 593__ $$aEndocrinology, Diabetes and Metabolism$$c2023$$dQ1
000149883 593__ $$aNutrition and Dietetics$$c2023$$dQ1
000149883 593__ $$aMedicine (miscellaneous)$$c2023$$dQ1
000149883 594__ $$a10.0$$b2023
000149883 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000149883 700__ $$0(orcid)0000-0002-5228-248X$$aSanz-Rubio, D.
000149883 700__ $$aClavería, P.
000149883 700__ $$aCabrejas, C.
000149883 700__ $$aFernando, J.
000149883 700__ $$aCastanera, A.
000149883 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J. M.$$uUniversidad de Zaragoza
000149883 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000149883 773__ $$g47 (2023), 24-32$$pInt. j. obes.$$tINTERNATIONAL JOURNAL OF OBESITY$$x0307-0565
000149883 8564_ $$s590136$$uhttps://zaguan.unizar.es/record/149883/files/texto_completo.pdf$$yPostprint
000149883 8564_ $$s2598793$$uhttps://zaguan.unizar.es/record/149883/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000149883 909CO $$ooai:zaguan.unizar.es:149883$$particulos$$pdriver
000149883 951__ $$a2025-10-17-14:28:18
000149883 980__ $$aARTICLE