000149886 001__ 149886
000149886 005__ 20251017144635.0
000149886 0247_ $$2doi$$a10.3389/fnagi.2017.00141
000149886 0248_ $$2sideral$$a133048
000149886 037__ $$aART-2017-133048
000149886 041__ $$aeng
000149886 100__ $$aCastano-Prat, Patricia
000149886 245__ $$aSlow and fast neocortical oscillations in the senescence-accelerated mouse model SAMP8
000149886 260__ $$c2017
000149886 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149886 5203_ $$aThe senescence-accelerated mouse prone 8 (SAMP8) model is characterized by accelerated, progressive cognitive decline as well as Alzheimer’s disease (AD)-like neurodegenerative changes, and resembles the etiology of multicausal, sporadic late-onset/age-related AD in humans. Our aim was to find whether these AD-like pathological features, together with the cognitive deficits present in the SAMP8 strain, are accompanied by disturbances in cortical network activity with respect to control mice (SAM resistance 1, SAMR1) and, if so, how the alterations in cortical activity progress with age. For this purpose, we characterized the extracellular spontaneous oscillatory activity in different regions of the cerebral cortex of SAMP8 and SAMR1 mice under ketamine anesthesia at 5 and 7 months of age. Under these conditions, slow oscillations and fast rhythms generated in the cortical network were recorded and different parameters of these oscillations were quantified and compared between SAMP8 and their control, SAMR1 mice. The average frequency of slow oscillations in SAMP8 mice was decreased with respect to the control mice at both studied ages. An elongation of the silent periods or Down states was behind the decreased slow oscillatory frequency while the duration of active or Up states remained stable. SAMP8 mice also presented increased cycle variability and reduced high frequency components during Down states. During Up states, the power peak in the gamma range was displaced towards lower frequencies in all the cortical areas of SAMP8 with respect to control mice suggesting that the spectral profile of SAMP8 animals is shifted towards lower frequencies. This shift is reminiscent to one of the principal hallmarks of electroencephalography (EEG) abnormalities in patients with Alzheimer’s disease, and adds evidence in support of the suitability of the SAMP8 mouse as a model of this disease. Although some of the differences between SAMP8 and control mice were emphasized with age, the evolution of the studied parameters as SAMR1 mice got older indicates that the SAMR1 phenotype tends to converge with that of SAMP8 animals. To our knowledge, this is the first systematic characterization of the cortical slow and fast rhythms in the SAMP8 strain and it provides useful insights about the cellular and synaptic mechanisms underlying the reported alterations.
000149886 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000149886 590__ $$a3.582$$b2017
000149886 591__ $$aNEUROSCIENCES$$b87 / 261 = 0.333$$c2017$$dQ2$$eT2
000149886 591__ $$aGERIATRICS & GERONTOLOGY$$b14 / 52 = 0.269$$c2017$$dQ2$$eT1
000149886 592__ $$a1.638$$b2017
000149886 593__ $$aAging$$c2017$$dQ1
000149886 593__ $$aCognitive Neuroscience$$c2017$$dQ2
000149886 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149886 700__ $$0(orcid)0000-0002-3194-7796$$aPerez-Zabalza, Maria
000149886 700__ $$aPerez-Mendez, Lorena
000149886 700__ $$aEscorihuela, Rosa M.
000149886 700__ $$aSanchez-Vives, Maria V.
000149886 773__ $$g9 (2017), 1-14$$pFrontiers in aging neuroscience$$tFrontiers in aging neuroscience$$x1663-4365
000149886 8564_ $$s3569965$$uhttps://zaguan.unizar.es/record/149886/files/texto_completo.pdf$$yVersión publicada
000149886 8564_ $$s2407046$$uhttps://zaguan.unizar.es/record/149886/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149886 909CO $$ooai:zaguan.unizar.es:149886$$particulos$$pdriver
000149886 951__ $$a2025-10-17-14:28:39
000149886 980__ $$aARTICLE