000149888 001__ 149888 000149888 005__ 20251017144635.0 000149888 0247_ $$2doi$$a10.1152/jn.00178.2010 000149888 0248_ $$2sideral$$a133047 000149888 037__ $$aART-2010-133047 000149888 041__ $$aeng 000149888 100__ $$aSanchez-Vives, Maria V. 000149888 245__ $$aInhibitory modulation of cortical up states 000149888 260__ $$c2010 000149888 5060_ $$aAccess copy available to the general public$$fUnrestricted 000149888 5203_ $$aThe balance between excitation and inhibition is critical in the physiology of the cerebral cortex. To understand the influence of inhibitory control on the emergent activity of the cortical network, inhibition was progressively blocked in a slice preparation that generates spontaneous rhythmic up states at a similar frequency to those occurring in vivo during slow-wave sleep or anesthesia. Progressive removal of inhibition induced a parametric shortening of up state duration and elongation of the down states, the frequency of oscillations decaying. Concurrently, a gradual increase in the network firing rate during up states occurred. The slope of transitions between up and down states was quantified for different levels of inhibition. The slope of upward transitions reflects the recruitment of the local network and was progressively increased when inhibition was decreased, whereas the speed of activity propagation became faster. Removal of inhibition eventually resulted in epileptiform activity. Whereas gradual reduction of inhibition induced linear changes in up/down states and their propagation, epileptiform activity was the result of a nonlinear transformation. A computational network model showed that strong recurrence plus activity-dependent hyperpolarizing currents were sufficient to account for the observed up state modulations and predicted an increase in activity-dependent hyperpolarization following up states when inhibition was decreased, which was confirmed experimentally. 000149888 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000149888 590__ $$a3.114$$b2010 000149888 591__ $$aPHYSIOLOGY$$b28 / 78 = 0.359$$c2010$$dQ2$$eT2 000149888 591__ $$aNEUROSCIENCES$$b100 / 237 = 0.422$$c2010$$dQ2$$eT2 000149888 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion 000149888 700__ $$aMattia, Maurizio 000149888 700__ $$aCompte, Albert 000149888 700__ $$0(orcid)0000-0002-3194-7796$$aPerez-Zabalza, Maria 000149888 700__ $$aWinograd, Milena 000149888 700__ $$aDescalzo, Vanessa F. 000149888 700__ $$aRoig, Ramon. 000149888 773__ $$g104, 3 (2010), 1314-1324$$pJ. neurophysiol.$$tJOURNAL OF NEUROPHYSIOLOGY$$x0022-3077 000149888 8564_ $$s815028$$uhttps://zaguan.unizar.es/record/149888/files/texto_completo.pdf$$yPostprint 000149888 8564_ $$s735247$$uhttps://zaguan.unizar.es/record/149888/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000149888 909CO $$ooai:zaguan.unizar.es:149888$$particulos$$pdriver 000149888 951__ $$a2025-10-17-14:28:41 000149888 980__ $$aARTICLE