000149890 001__ 149890
000149890 005__ 20250128160611.0
000149890 0247_ $$2doi$$a10.1016/j.neuroscience.2018.04.035
000149890 0248_ $$2sideral$$a133053
000149890 037__ $$aART-2018-133053
000149890 041__ $$aeng
000149890 100__ $$aRebollo, Beatriz
000149890 245__ $$aBeta and gamma oscillations in prefrontal cortex during NMDA hypofunction: an in vitro model of schizophrenia features
000149890 260__ $$c2018
000149890 5203_ $$aNMDA receptor (NMDAr) hypofunction has been widely used as a schizophrenia model. Decreased activation of NMDAr is associated with a disrupted excitation/inhibition balance in the prefrontal cortex and with alterations in gamma synchronization. Our aim was to investigate whether this phenomenon could be reproduced in the spontaneous oscillatory activity generated by the local prefrontal network in vitro and, if so, to explore the effects of antipsychotics on the resulting activity. Extracellular recordings were obtained from prefrontal cortex slices bathed in in vivo-like ACSF solution. Slow (<1 Hz) oscillations consisting of interspersed Up (active) and Down (silent) states spontaneously emerged. Fast-frequency oscillations (15–90 Hz) occurred during Up states. We explored the effects of the NMDAr antagonist MK-801 on the spontaneously generated activity. Bath-applied MK-801 induced a dose-dependent decrease in Up-state duration and in the frequency of Up states. However, the beta/gamma power during Up states significantly increased; this increase was in turn prevented by the antipsychotic drug clozapine. The increased beta/gamma power with NMDAr blockade implies that NMDAr activation in physiological conditions prevents hypersynchronization in this frequency range. High-frequency hypersynchronization following NMDAr blockade occurring in cortical slices suggests that—at least part of—the underlying mechanisms of this schizophrenia feature persist in the local cortical circuit, even in the absence of long-range cortical or subcortical inputs. The observed action of clozapine decreasing hypersynchronization in the local circuit may be one of the mechanisms of action of clozapine in preventing schizophrenia symptoms derived from NMDA hypofunction.
000149890 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000149890 590__ $$a3.244$$b2018
000149890 591__ $$aNEUROSCIENCES$$b112 / 266 = 0.421$$c2018$$dQ2$$eT2
000149890 592__ $$a1.484$$b2018
000149890 593__ $$aNeuroscience (miscellaneous)$$c2018$$dQ2
000149890 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149890 700__ $$0(orcid)0000-0002-3194-7796$$aPerez-Zabalza, Maria
000149890 700__ $$aRuiz-Mejias, Marcel
000149890 700__ $$aPerez-Mendez, Lorena
000149890 700__ $$aSanchez-Vives, Maria V.
000149890 773__ $$g383 (2018), 138-149$$pNeuroscience$$tNEUROSCIENCE$$x0306-4522
000149890 8564_ $$s2044069$$uhttps://zaguan.unizar.es/record/149890/files/texto_completo.pdf$$yVersión publicada
000149890 8564_ $$s3072208$$uhttps://zaguan.unizar.es/record/149890/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149890 909CO $$ooai:zaguan.unizar.es:149890$$particulos$$pdriver
000149890 951__ $$a2025-01-28-14:58:06
000149890 980__ $$aARTICLE