000149898 001__ 149898
000149898 005__ 20250130163249.0
000149898 0247_ $$2doi$$a10.1016/j.ttbdis.2023.102281
000149898 0248_ $$2sideral$$a137330
000149898 037__ $$aART-2024-137330
000149898 041__ $$aeng
000149898 100__ $$aBaz-Flores, Sara
000149898 245__ $$aMapping the risk of exposure to Crimean-Congo haemorrhagic fever virus in the Iberian Peninsula using Eurasian wild boar (Sus scrofa) as a model
000149898 260__ $$c2024
000149898 5060_ $$aAccess copy available to the general public$$fUnrestricted
000149898 5203_ $$aCrimean-Congo haemorrhagic fever (CCHF) virus (CCHFV) is a tick-borne zoonotic pathogen that can cause a lethal haemorrhagic disease in humans. Although the virus appears to be endemically established in the Iberian Peninsula, CCHF is an emerging disease in Spain. Clinical signs of CCHFV infection are mainly manifested in humans, but the virus replicates in several animal species. Understanding the determinants of CCHFV exposure risk from animal models is essential to predicting high-risk exposure hotspots for public health action. With this objective in mind, we designed a cross-sectional study of Eurasian wild boar (Sus scrofa) in Spain and Portugal. The study analysed 5,291 sera collected between 2006 and 2022 from 90 wild boar populations with a specific double-antigen ELISA to estimate CCHFV serum prevalence and identify the main determinants of exposure probability. To do so, we statistically modelled exposure risk with host- and environment-related predictors and spatially projected it at a 10 × 10 km square resolution at the scale of the Iberian Peninsula to map foci of infection risk. Fifty-seven (63.3 %) of the 90 populations had at least one seropositive animal, with seroprevalence ranging from 0.0 to 88.2 %. Anti-CCHFV antibodies were found in 1,026 of 5,291 wild boar (19.4 %; 95 % confidence interval: 18.3–20.5 %), with highest exposure rates in southwestern Iberia. The most relevant predictors of virus exposure risk were wild boar abundance, local rainfall regime, shrub cover, winter air temperature and soil temperature variation. The spatial projection of the best-fit model identified high-risk foci as occurring in most of western and southwestern Iberia and identified recently confirmed risk foci in eastern Spain. The results of the study demonstrate that serological surveys of CCHFV vector hosts are a powerful, robust and highly informative tool for public health authorities to take action to prevent human cases of CCHF in enzootic and emergency settings.
000149898 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/TED2021–132599B-C21/22
000149898 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000149898 590__ $$a3.1$$b2023
000149898 591__ $$aPARASITOLOGY$$b10 / 45 = 0.222$$c2023$$dQ1$$eT1
000149898 591__ $$aINFECTIOUS DISEASES$$b52 / 132 = 0.394$$c2023$$dQ2$$eT2
000149898 591__ $$aMICROBIOLOGY$$b78 / 161 = 0.484$$c2023$$dQ2$$eT2
000149898 592__ $$a1.021$$b2023
000149898 593__ $$aInfectious Diseases$$c2023$$dQ1
000149898 593__ $$aParasitology$$c2023$$dQ1
000149898 593__ $$aInsect Science$$c2023$$dQ1
000149898 593__ $$aMicrobiology$$c2023$$dQ2
000149898 594__ $$a6.9$$b2023
000149898 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149898 700__ $$aHerraiz, Cesar
000149898 700__ $$aPeralbo-Moreno, Alfonso
000149898 700__ $$aBarral, Marta
000149898 700__ $$0(orcid)0000-0002-6770-3400$$aArnal, Mari Cruz$$uUniversidad de Zaragoza
000149898 700__ $$aBalseiro, Ana
000149898 700__ $$aCano-Terriza, David
000149898 700__ $$aCastro-Scholten, Sabrina
000149898 700__ $$aCevidanes, Aitor
000149898 700__ $$aConde-Lizarralde, Alazne
000149898 700__ $$aCuadrado-Matías, Raúl
000149898 700__ $$aEscribano, Fernando
000149898 700__ $$0(orcid)0000-0003-3289-4267$$ade Luco, Daniel Fernández$$uUniversidad de Zaragoza
000149898 700__ $$aFidalgo, Luis Eusebio
000149898 700__ $$aHermoso-de Mendoza, Javier
000149898 700__ $$aFandos, Paulino
000149898 700__ $$aGómez-Guillamón, Félix
000149898 700__ $$aGranados, José E.
000149898 700__ $$aJiménez-Martín, Débora
000149898 700__ $$aLópez-Olvera, Jorge R.
000149898 700__ $$aMartín, Inés
000149898 700__ $$aMartínez, Remigio
000149898 700__ $$aMentaberre, Gregorio
000149898 700__ $$aGarcía-Bocanegra, Ignacio
000149898 700__ $$aRuiz-Fons, Francisco
000149898 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000149898 773__ $$g15, 1 (2024), 102281 [9 pp.]$$pTicks Tick-borne Dis.$$tTicks and Tick-borne Diseases$$x1877-959X
000149898 8564_ $$s1279108$$uhttps://zaguan.unizar.es/record/149898/files/texto_completo.pdf$$yVersión publicada
000149898 8564_ $$s2512507$$uhttps://zaguan.unizar.es/record/149898/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149898 909CO $$ooai:zaguan.unizar.es:149898$$particulos$$pdriver
000149898 951__ $$a2025-01-30-16:31:32
000149898 980__ $$aARTICLE