000149900 001__ 149900
000149900 005__ 20251017144638.0
000149900 0247_ $$2doi$$a10.1164/rccm.201602-0320OC
000149900 0248_ $$2sideral$$a114845
000149900 037__ $$aART-2017-114845
000149900 041__ $$aeng
000149900 100__ $$aBéduneau, Gaëtan
000149900 245__ $$aEpidemiology of Weaning Outcome according to a New Definition. The WIND Study
000149900 260__ $$c2017
000149900 5203_ $$aRATIONALE:
The weaning process concerns all patients receiving mechanical ventilation. A previous classification into simple, prolonged, and difficult weaning ignored weaning failure and presupposed the use of spontaneous breathing trials.
OBJECTIVES:
To describe the weaning process, defined as starting with any attempt at separation from mechanical ventilation and its prognosis, according to a new operational classification working for all patients under ventilation.
METHODS:
This was a multinational prospective multicenter observational study over 3 months of all patients receiving mechanical ventilation in 36 intensive care units, with daily collection of ventilation and weaning modalities. Pragmatic definitions of separation attempt and weaning success allowed us to allocate patients in four groups.
MEASUREMENTS AND MAIN RESULTS:
A total of 2,729 patients were enrolled. Although half of them could not be classified using the previous definition, 99% entered the groups on the basis of our new definition as follows: 24% never started a weaning process, 57% had a weaning process of less than 24 hours (group 1), 10% had a difficult weaning of more than 1 day and less than 1 week (group 2), and 9% had a prolonged weaning duration of 1 week or more (group 3). Duration of ventilation, intensive care unit stay, and mortality (6, 17, and 29% for the three groups, respectively) all significantly increased from one group to the next. The unadjusted risk of dying was 19% after the first separation attempt and increased to 37% after 10 days.
CONCLUSIONS:
A new classification allows us to categorize all weaning situations. Every additional day without a weaning success after the first separation attempt increases the risk of dying.
000149900 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000149900 590__ $$a15.239$$b2017
000149900 591__ $$aCRITICAL CARE MEDICINE$$b2 / 33 = 0.061$$c2017$$dQ1$$eT1
000149900 591__ $$aRESPIRATORY SYSTEM$$b2 / 59 = 0.034$$c2017$$dQ1$$eT1
000149900 592__ $$a5.942$$b2017
000149900 593__ $$aPulmonary and Respiratory Medicine$$c2017$$dQ1
000149900 593__ $$aCritical Care and Intensive Care Medicine$$c2017$$dQ1
000149900 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000149900 700__ $$aPham, Tài
000149900 700__ $$aSchortgen, Frédérique
000149900 700__ $$aPiquilloud, Lise
000149900 700__ $$aZogheib, Elie
000149900 700__ $$aJonas, Maud
000149900 700__ $$aGrelon, Fabien
000149900 700__ $$aRunge, Isabelle
000149900 700__ $$aNicolas Terzi
000149900 700__ $$aGrangé, Steven
000149900 700__ $$aBarberet, Guillaume
000149900 700__ $$aGuitard, Pierre-Gildas
000149900 700__ $$aFrat, Jean-Pierre
000149900 700__ $$aConstan, Adrien
000149900 700__ $$aChretien, Jean-Marie
000149900 700__ $$aMancebo, Jordi
000149900 700__ $$aMercat, Alain
000149900 700__ $$aRichard, Jean-Christophe M.
000149900 700__ $$aBrochard, Laurent
000149900 700__ $$0(orcid)0000-0002-2290-4807$$aZalba-Etayo, B.$$uUniversidad de Zaragoza
000149900 700__ $$aRaventos-Irigoyen, N.
000149900 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000149900 773__ $$g195, 6 (2017), 772-783$$pAm. j. respir. crit. care med.$$tAmerican Journal of Respiratory and Critical Care Medicine$$x1073-449X
000149900 8564_ $$s794410$$uhttps://zaguan.unizar.es/record/149900/files/texto_completo.pdf$$yVersión publicada
000149900 8564_ $$s3054480$$uhttps://zaguan.unizar.es/record/149900/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000149900 909CO $$ooai:zaguan.unizar.es:149900$$particulos$$pdriver
000149900 951__ $$a2025-10-17-14:30:22
000149900 980__ $$aARTICLE