150140 20260217205528.0 doi 10.1002/ejic.202400511 sideral 142434 ART-2024-142434 eng Pantoja-Romero, Wenndy Andrographolide Encapsulation in Metal-Organic Frameworks (MOFs) via Solvent-Free Process at High Pressure 2024 Access copy available to the general public Unrestricted Andrographolide (ADG) encapsulation was carried out on MOFs MIL‐53(Al) and ZIF‐8 by high‐pressure (0.3 GPa) contact. This methodology is not only environment‐friendly but also energy/time‐saving and gives rise to ADG‐MOFs with physical features equivalent to those of materials obtained by common liquid phase encapsulation. The loaded MOFs were characterized through TEM, SEM, XRD, TGA, FT‐IR, BET, and NMR. The observed decrease in the intensity of ADG XRD peaks is due to the adsorption of ADG into the MOFs. TGA showed the decomposition step of ADG in the range of 200–300 °C in both loaded MOFs. FT‐IR also showed intense signals of the ADG in the synthesized materials. The dissolution profile of ADG in MIL‐53(Al) in PBS (pH=7.4) was carried out showing that the drug was released up to 96 % after 75 h. Solid‐state NMR confirmed the interactions between ADG molecules and ZIF‐8 groups and the formation of a hydrogen bond between the carboxylic group of ADG and the hydroxyl group of MIL‐53(Al). Coefficient partition studies determined that both MOFs did not improve the hydrophilicity of the ADG, due to the loading of the drug preferably occurring by interactions in the hydrophobic areas within the pores of the MOFs. info:eu-repo/grantAgreement/ES/DGA/T68-23R info:eu-repo/grantAgreement/ES/MICINN/PID2022-138582OB-I00 info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 2.0 2024 CHEMISTRY, INORGANIC & NUCLEAR 24 / 43 = 0.558 2024 Q3 T2 0.459 2024 Inorganic Chemistry 2024 Q2 3.9 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aysa-Martínez, Yolanda Lavín-Flores, Alexis Medina-Berrios, Nataniel Bayro, Marvin J. Morell, Gerardo Weiner, Brad R. Coronas, Joaquín Universidad de Zaragoza (orcid)0000-0003-1512-4500 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 27, 36 (2024), e202400511 [8 pp.] Eur. j. inorg. chem. European Journal of Inorganic Chemistry 1434-1948 1630321 http://zaguan.unizar.es/record/150140/files/texto_completo.pdf Versión publicada 2861466 http://zaguan.unizar.es/record/150140/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150140 articulos driver 2026-02-17-20:31:30 ARTICLE