000150158 001__ 150158
000150158 005__ 20251017144654.0
000150158 0247_ $$2doi$$a10.1021/acs.macromol.4c01403
000150158 0248_ $$2sideral$$a141132
000150158 037__ $$aART-2024-141132
000150158 041__ $$aeng
000150158 100__ $$0(orcid)0009-0008-6456-4856$$aBescós-Ramo, Sara$$uUniversidad de Zaragoza
000150158 245__ $$aAmino-yne reaction for the synthesis of degradable hydrogels: Study of the cleavage of ß-Aminoacrylate Cross-Links
000150158 260__ $$c2024
000150158 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150158 5203_ $$aThis work addresses a study of PEG-derived hydrogels based on β-aminoacrylate cross-links and obtained by amino-yne click chemistry, using a β-aminoacrylate-based model molecule as reference. The pH-triggered cleavage of the β-aminoacrylate bonds was monitored confirming not only the release of the conjugated amine but also the formation of a mixture of chemical species that depends on the acidity of the medium. Moreover, overall hydrogel degradation rates were able to be adjusted by modifying pH, temperature, polymer concentration, or the amine selected as linker of PEG chains. In particular, the labile nature of the β-aminoacrylate bond was confirmed even under physiological conditions (pH 7.4, 37 °C), leading to long-term material degradation. The release and recovery of the conjugated amine after the cleavage of the β-aminoacrylate bonds was demonstrated at both acidic and physiological pH, mimicking the results acquired through model molecule studies.
000150158 536__ $$9info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S$$9info:eu-repo/grantAgreement/ES/DGA/E47-23R$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-126132NB-I00
000150158 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000150158 590__ $$a5.2$$b2024
000150158 592__ $$a1.352$$b2024
000150158 591__ $$aPOLYMER SCIENCE$$b15 / 94 = 0.16$$c2024$$dQ1$$eT1
000150158 593__ $$aInorganic Chemistry$$c2024$$dQ1
000150158 593__ $$aPolymers and Plastics$$c2024$$dQ1
000150158 593__ $$aOrganic Chemistry$$c2024$$dQ1
000150158 593__ $$aMaterials Chemistry$$c2024$$dQ1
000150158 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150158 700__ $$0(orcid)0000-0002-5380-6863$$aBarrio Lasheras, Jesús del$$uUniversidad de Zaragoza
000150158 700__ $$0(orcid)0000-0003-1378-0571$$aRomero, Pilar
000150158 700__ $$aFlorentino-Madiedo, Laura$$uUniversidad de Zaragoza
000150158 700__ $$0(orcid)0000-0001-5556-2172$$aPiñol, Milagros$$uUniversidad de Zaragoza
000150158 700__ $$0(orcid)0000-0002-0922-5615$$aOriol, Luis$$uUniversidad de Zaragoza
000150158 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000150158 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000150158 773__ $$g57, 23 (2024), 10926-10937$$pMacromolecules$$tMACROMOLECULES$$x0024-9297
000150158 8564_ $$s6014354$$uhttps://zaguan.unizar.es/record/150158/files/texto_completo.pdf$$yVersión publicada
000150158 8564_ $$s3102659$$uhttps://zaguan.unizar.es/record/150158/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150158 909CO $$ooai:zaguan.unizar.es:150158$$particulos$$pdriver
000150158 951__ $$a2025-10-17-14:37:45
000150158 980__ $$aARTICLE