000150304 001__ 150304
000150304 005__ 20250203110924.0
000150304 0247_ $$2doi$$a10.1007/s10439-015-1299-2
000150304 0248_ $$2sideral$$a91234
000150304 037__ $$aART-2015-91234
000150304 041__ $$aeng
000150304 100__ $$0(orcid)0000-0002-8503-9291$$aCilla, M.
000150304 245__ $$aEffect of Transmural Transport Properties on Atheroma Plaque Formation and Development
000150304 260__ $$c2015
000150304 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150304 5203_ $$aWe propose a mathematical model of atheroma plaque initiation and early development in coronary arteries using anisotropic transmural diffusion properties. Our current approach is on the process on plaque initiation and intimal thickening rather than in severe plaque progression and rupture phenomena. The effect of transport properties, in particular the anisotropy of diffusion properties of the artery, on plaque formation and development is investigated using the proposed mathematical model. There is not a strong influence of the anisotropic transmural properties on LDL, SMCs and collagen distribution and concentrations along the artery. On the contrary, foam cells distribution strongly depends on the value of the radial diffusion coefficient of the substances and the ratio . Decreasing or diffusion coefficients ratio means a higher concentration of the foam cells close to the intima. Due to the fact that foam cells concentration is associated to the necrotic core formation, the final distribution of foam cells is critical to evolve into a vulnerable or fibrotic plaque.
000150304 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391
000150304 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000150304 590__ $$a2.887$$b2015
000150304 591__ $$aENGINEERING, BIOMEDICAL$$b16 / 76 = 0.211$$c2015$$dQ1$$eT1
000150304 592__ $$a1.2$$b2015
000150304 593__ $$aBiomedical Engineering$$c2015$$dQ1
000150304 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000150304 700__ $$0(orcid)0000-0002-8375-0354$$aMartínez, M. A.$$uUniversidad de Zaragoza
000150304 700__ $$0(orcid)0000-0002-0664-5024$$aPeña, E.$$uUniversidad de Zaragoza
000150304 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000150304 773__ $$g43, 7 (2015), 1516-1530$$pAnn. biomed. eng.$$tAnnals of Biomedical Engineering$$x0090-6964
000150304 8564_ $$s9882573$$uhttps://zaguan.unizar.es/record/150304/files/texto_completo.pdf$$yPostprint
000150304 8564_ $$s2933302$$uhttps://zaguan.unizar.es/record/150304/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000150304 909CO $$ooai:zaguan.unizar.es:150304$$particulos$$pdriver
000150304 951__ $$a2025-02-03-10:49:13
000150304 980__ $$aARTICLE