150304 20251017144548.0 doi 10.1007/s10439-015-1299-2 sideral 91234 ART-2015-91234 eng Cilla, M. (orcid)0000-0002-8503-9291 Effect of Transmural Transport Properties on Atheroma Plaque Formation and Development 2015 Access copy available to the general public Unrestricted We propose a mathematical model of atheroma plaque initiation and early development in coronary arteries using anisotropic transmural diffusion properties. Our current approach is on the process on plaque initiation and intimal thickening rather than in severe plaque progression and rupture phenomena. The effect of transport properties, in particular the anisotropy of diffusion properties of the artery, on plaque formation and development is investigated using the proposed mathematical model. There is not a strong influence of the anisotropic transmural properties on LDL, SMCs and collagen distribution and concentrations along the artery. On the contrary, foam cells distribution strongly depends on the value of the radial diffusion coefficient of the substances and the ratio . Decreasing or diffusion coefficients ratio means a higher concentration of the foam cells close to the intima. Due to the fact that foam cells concentration is associated to the necrotic core formation, the final distribution of foam cells is critical to evolve into a vulnerable or fibrotic plaque. info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391 info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 2.887 2015 ENGINEERING, BIOMEDICAL 16 / 76 = 0.211 2015 Q1 T1 1.2 2015 Biomedical Engineering 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Martínez, M. A. Universidad de Zaragoza (orcid)0000-0002-8375-0354 Peña, E. Universidad de Zaragoza (orcid)0000-0002-0664-5024 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 43, 7 (2015), 1516-1530 Ann. biomed. eng. Annals of Biomedical Engineering 0090-6964 9882573 http://zaguan.unizar.es/record/150304/files/texto_completo.pdf Postprint 2933302 http://zaguan.unizar.es/record/150304/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:150304 articulos driver 2025-10-17-14:10:41 ARTICLE