150339 20251017144646.0 doi 10.1371/journal.pone.0237186 sideral 142515 ART-2020-142515 eng Lopez-Rodriguez, Juan A. Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study 2020 Access copy available to the general public Unrestricted Background Multimorbidity is a global health challenge that is associated with polypharmacy, increasing the risk of potentially inappropriate prescribing (PIP). There are tools to improve prescription, such as implicit and explicit criteria. Objective To estimate the prevalence of PIP in a population aged 65 to 74 years with multimorbidity and polypharmacy, according to American Geriatrics Society Beers Criteria® (2015, 2019), the Screening Tool of Older Person’s Prescription -STOPP- criteria (2008, 2014), and the Medication Appropriateness Index -MAI- criteria in primary care. Methods This was an observational, descriptive, cross-sectional study. The sample included 593 community-dwelling elderly aged 65 to 74 years, with multimorbidity and polypharmacy, who participated in the MULTIPAP trial. Socio-demographic, clinical, professional, and pharmacological-treatment variables were recorded. Potentially inappropriate prescribing was detected by computerized prescription assistance system, and family doctors evaluated the MAI. The MAI-associated factors were analysed using a logistic regression model. Results A total of 4,386 prescriptions were evaluated. The mean number of drugs was 7.4 (2.4 SD). A total of 94.1% of the patients in the study had at least one criterion for drug inappropriateness according to the MAI. Potentially inappropriate prescribing was detected in 57.7%, 43.6%, 68.8% and 71% of 50 patients according to the explicit criteria STOPP 2014, STOPP 2008, Beers 2019 and Beers 2015 respectively. For every new drug taken by a patient, the MAI score increased by 2.41 (95% CI 1.46; 3.35) points. Diabetes, ischaemic heart disease and asthma were independently associated with lower summated MAI scores. Conclusions The prevalence of potentially inappropriate prescribing detected in the sample was high and in agreement with previous literature for populations with multimorbidity and polypharmacy. The MAI criteria detected greater inappropriateness than did the explicit criteria, but their application was more complex and difficult to automate. Figures info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0001-0004 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00276 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00572 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-00996 info:eu-repo/grantAgreement/ES/ISCIII/RD16-0001-0005 info:eu-repo/grantAgreement/ES/ISCIII/RD16-0001-0006 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.24 2020 MULTIDISCIPLINARY SCIENCES 25 / 71 = 0.352 2020 Q2 T2 0.99 2020 Multidisciplinary 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rogero-Blanco, Eloísa Aza-Pascual-Salcedo, Mercedes Lopez-Verde, Fernando Pico-Soler, Victoria Leiva-Fernandez, Francisca Prados-Torres, J. Daniel Prados-Torres, Alexandra Cura-González, Isabel Gimeno Feliu Luis Universidad de Zaragoza (orcid)0000-0003-2928-6623 on behalf MULTIPAP group 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 15, 8 (2020), e0237186 [20 pp.] PLoS One PLoS ONE 1932-6203 914877 http://zaguan.unizar.es/record/150339/files/texto_completo.pdf Versión publicada 2182287 http://zaguan.unizar.es/record/150339/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150339 articulos driver 2025-10-17-14:34:07 ARTICLE