000150366 001__ 150366
000150366 005__ 20250203171510.0
000150366 0247_ $$2doi$$a10.1080/13814788.2021.1917543
000150366 0248_ $$2sideral$$a142513
000150366 037__ $$aART-2021-142513
000150366 041__ $$aeng
000150366 100__ $$aRogero-Blanco, Eloísa
000150366 245__ $$aDrug interactions detected by a computer-assisted prescription system in primary care patients in Spain: MULTIPAP study
000150366 260__ $$c2021
000150366 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150366 5203_ $$aBackground
Drug interactions increase the risk of treatment failure, intoxication, hospital admissions, consultations and mortality. Computer-assisted prescription systems can help to detect interactions.
Objectives
To describe the drug–drug interaction (DDI) and drug–disease interaction (DdI) prevalence identified by a computer-assisted prescription system in patients with multimorbidity and polypharmacy. Factors associated with clinically relevant interactions were analysed.
Methods
Observational, descriptive, cross-sectional study in primary health care centres was undertaken in Spain. The sample included 593 patients aged 65–74 years with multimorbidity and polypharmacy participating in the MULTIPAP Study, recruited from November 2016 to January 2017. Drug interactions were identified by a computer-assisted prescription system. Descriptive, bivariate, and multivariate analyses with logistic regression models and robust estimators were performed.
Results
Half (50.1% (95% CI 46.1–54.1)) of the patients had at least one relevant DDI and 23.9% (95% CI 18.9–25.6) presented with a DdI. Non-opioid–central nervous system depressant drug combinations and benzodiazepine–opioid drug combinations were the two most common clinically relevant interactions (10.8% and 5.9%, respectively). Factors associated with DDI were the use of more than 10 drugs (OR 11.86; 95% CI 6.92–20.33) and having anxiety/depressive disorder (OR 1.98; 95% CI 1.31–2.98). Protective factors against DDI were hypertension (OR 0.62; 95% CI 0.41–0.94), diabetes (OR 0.57; 95% CI 0.40–0.82), and ischaemic heart disease (OR 0.43; 95% CI 0.25–0.74).
Conclusion
Drug interactions are prevalent in patients aged 65–74 years with multimorbidity and polypharmacy. The clinically relevant DDI frequency is low. The number of prescriptions taken is the most relevant factor associated with presenting a clinically relevant DDI.
000150366 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0001-0004$$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-01303$$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-01515$$9info:eu-repo/grantAgreement/ES/ISCIII/PI18-01812$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0001-0005$$9info:eu-repo/grantAgreement/ES/ISCIII/RD16-0001-0006
000150366 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000150366 590__ $$a3.636$$b2021
000150366 591__ $$aPRIMARY HEALTH CARE$$b4 / 18 = 0.222$$c2021$$dQ1$$eT1
000150366 591__ $$aMEDICINE, GENERAL & INTERNAL$$b66 / 172 = 0.384$$c2021$$dQ2$$eT2
000150366 592__ $$a1.689$$b2021
000150366 593__ $$aMedicine (miscellaneous)$$c2021$$dQ1
000150366 593__ $$aFamily Practice$$c2021$$dQ1
000150366 594__ $$a8.5$$b2021
000150366 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150366 700__ $$aDel-Cura-González, Isabel
000150366 700__ $$aAza-Pascual-Salcedo, Mercedes
000150366 700__ $$aGarcía de Blas González, Francisca
000150366 700__ $$aTerrón-Rodas, Carmen
000150366 700__ $$aChimeno-Sánchez, Sergio
000150366 700__ $$aGarcía-Domingo, Eva
000150366 700__ $$aLópez-Rodríguez, Juan A.
000150366 700__ $$0(orcid)0000-0003-2928-6623$$aGimeno Feliu, Luis$$uUniversidad de Zaragoza
000150366 700__ $$aon behalf MULTIPAP group
000150366 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000150366 773__ $$g27, 1 (2021), 90-96$$pEur. j. gen. pract$$tEUROPEAN JOURNAL OF GENERAL PRACTICE$$x1381-4788
000150366 8564_ $$s1514884$$uhttps://zaguan.unizar.es/record/150366/files/texto_completo.pdf$$yVersión publicada
000150366 8564_ $$s1321960$$uhttps://zaguan.unizar.es/record/150366/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150366 909CO $$ooai:zaguan.unizar.es:150366$$particulos$$pdriver
000150366 951__ $$a2025-02-03-14:49:42
000150366 980__ $$aARTICLE