000150454 001__ 150454
000150454 005__ 20250203191514.0
000150454 0247_ $$2doi$$a10.1021/acschemneuro.4c00297
000150454 0248_ $$2sideral$$a142562
000150454 037__ $$aART-2024-142562
000150454 041__ $$aeng
000150454 100__ $$aRuiz-Sobremazas, Diego$$uUniversidad de Zaragoza
000150454 245__ $$aFrom Nutritional Patterns to Behavior: High-Fat Diet Influences on Inhibitory Control, Brain Gene Expression, and Metabolomics in Rats
000150454 260__ $$c2024
000150454 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150454 5203_ $$aImpulsive and compulsive behaviors are associated with inhibitory control deficits. Diet plays a pivotal role in normal development, impacting both physiology and behavior. However, the specific effects of a high-fat diet (HFD) on inhibitory control have not received adequate attention. This study aimed to explore how exposure to a HFD from postnatal day (PND) 33 to PND77 affects impulsive and compulsive behaviors. The experiment involved 40 Wistar rats subjected to HFD or chow diets. Several tasks were employed to assess behavior, including variable delay to signal (VDS), five choice serial reaction time task (5-CSRTT), delay discounting task (DDT), and rodent gambling task (rGT). Genetic analyses were performed on the frontal cortex, and metabolomics and fatty acid profiles were examined by using stool samples collected on PND298. Our results showed that the HFD group exhibited increased motor impulsive behaviors while not affecting cognitive impulsivity. Surprisingly, reduced impulsive decision-making was shown in the HFD group. Furthermore, abnormal brain plasticity and dopamine gene regulation were shown in the frontal cortex, while metabolomics revealed abnormal fatty acid levels.
000150454 536__ $$9info:eu-repo/grantAgreement/ES/AEI/PID2022-139286NB-I00$$9info:eu-repo/grantAgreement/ES/PND/2022I024
000150454 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000150454 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150454 700__ $$aAbreu, Ana Cristina
000150454 700__ $$aPrados-Pardo, Ángeles
000150454 700__ $$aMartín-González, Elena
000150454 700__ $$aTristán, Ana Isabel
000150454 700__ $$aFernández, Ignacio
000150454 700__ $$aMoreno, Margarita
000150454 700__ $$aMora, Santiago
000150454 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000150454 773__ $$g15, 24 (2024), 4369-4382$$pACS CHEMICAL NEUROSCIENCE$$tACS CHEMICAL NEUROSCIENCE$$x1948-7193
000150454 8564_ $$s5467915$$uhttps://zaguan.unizar.es/record/150454/files/texto_completo.pdf$$yVersión publicada
000150454 8564_ $$s3234484$$uhttps://zaguan.unizar.es/record/150454/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150454 909CO $$ooai:zaguan.unizar.es:150454$$particulos$$pdriver
000150454 951__ $$a2025-02-03-17:41:57
000150454 980__ $$aARTICLE