000150528 001__ 150528
000150528 005__ 20251017144642.0
000150528 0247_ $$2doi$$a10.47739/2475-9155/1031
000150528 0248_ $$2sideral$$a142644
000150528 037__ $$aART-2021-142644
000150528 041__ $$aeng
000150528 100__ $$0(orcid)0000-0002-1609-5994$$aSatue, M.$$uUniversidad de Zaragoza
000150528 245__ $$aQuantification of progressive retinal thinning in patients with fibromyalgia syndrome over a period of 5 years
000150528 260__ $$c2021
000150528 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150528 5203_ $$aPurpose: To quantify changes in visual function parameters and the macular neuroretina of patients with Fibromyalgia (FM) over 5 years, compared with controls.
Methods: Eighty patients with FM and 38 healthy subjects were included in a prospective observational study and underwent visual acuity (VA) evaluation with ETDRS chart, contrast sensitivity vision (CSV) with CSV 1000E test, and retinal evaluation using Spectralis Optical coherence tomography (OCT). All subjects were re-evaluated after 5 years to quantify changes in visual function parameters and ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thickness. The relationship between progressive structural, functional and disease severity changes was analysed. Additionally, patients were classified into three different groups to analyse progression depending on the disease phenotype.
Results: When compared with controls, patients with FM presented worse low contrast VA (p=0.024), and low frequency CSV (p=0.004) after a 5-year follow up. A progressive decrease affecting the GCL thickness (nasal 1, p=0.004; temporal 1, p<0.001; inferior 1, p=0.001) and the RNFL (nasal 1 and 2, p<0.001; superior 1, p<0.001; and inferior 1, p=0.002) was observed in patients over the monitoring time. Changes affecting the GCL were correlated with progression in disease severity scores (EQ-5D, r=0.560, p<0.001; FIQ, r=-0.470, p=0.003). Correlations between structural changes and disease severity scores were only observed in the atypical and biologic phenotypes.
Conclusions: Progressive visual dysfunction and retinal neurodegeneration was detected in FM patients. The evaluation of visual parameters and GCL/ RNFL thickness using SD-OCT can be useful to monitor FM progression.
000150528 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CM17-00010$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726
000150528 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000150528 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150528 700__ $$aVicente, M.J.
000150528 700__ $$aPerez-Velilla, J.
000150528 700__ $$aTello, A.
000150528 700__ $$0(orcid)0000-0001-9411-5834$$aVilades, E.$$uUniversidad de Zaragoza
000150528 700__ $$0(orcid)0000-0003-2710-1875$$aOrduna, E.$$uUniversidad de Zaragoza
000150528 700__ $$aCordon, B.$$uUniversidad de Zaragoza
000150528 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia-Campayo, J.$$uUniversidad de Zaragoza
000150528 700__ $$0(orcid)0000-0002-8862-7240$$aPuebla-Guedea, M.$$uUniversidad de Zaragoza
000150528 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000150528 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000150528 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000150528 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000150528 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000150528 773__ $$g4, 1 (2021), 1031 [8 pp.]$$pJSM arthritis$$tJSM arthritis$$x2475-9155
000150528 8564_ $$s1055987$$uhttps://zaguan.unizar.es/record/150528/files/texto_completo.pdf$$yVersión publicada
000150528 8564_ $$s2650172$$uhttps://zaguan.unizar.es/record/150528/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150528 909CO $$ooai:zaguan.unizar.es:150528$$particulos$$pdriver
000150528 951__ $$a2025-10-17-14:32:32
000150528 980__ $$aARTICLE