150547 20260217205549.0 doi 10.1016/j.numecd.2024.103811 sideral 142607 ART-2024-142607 eng Skapino, Estela Independent effect of body fat content on inflammatory biomarkers in children and adolescents: The GENOBOX study 2024 Access copy available to the general public Unrestricted Background and aims: To assess the relationship between body composition indicators and inflammatory bio-markers in children and adolescents of the GENOBOX study. Methods and results: Anthropometry data from 264 subjects from the subsample of Zaragoza (Spain) included: weight, height, waist circumference, body mass index and triponderal index. Body composition was determined by Dual-energy X-ray Absorptiometry (DXA), obtaining visceral adipose tissue, fat mass index and lean mass index. Age and sex specific z-scores were computed. Simple linear regression models were performed with in-flammatory biomarkers (hsCRP, IL8, TNF-α, adiponectin, leptin and resistin) as dependent variables, and each of the body composition indices as independent variables. Prepubertal boys had higher IL8 and resistin values and pubertal girls had higher HOMA-IR and leptin values. hsCPR and leptin were associated with fat mass, both in prepubertals and pubertals, independently of lean mass, and regardless of how body composition was measured. All body composition indices were inversely associated with adiponectin, except for fat mass index in pubertals, but none of them were statistically significant. Conclusion: A positive association between hsCRP and leptin with all body fat composition parameters, measured by standard nutritional indicators and DXA, was observed in both sexual stages. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI051968 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205 info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301 info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015 info:eu-repo/grantAgreement/ES/MEC/FPU16-03653 info:eu-repo/grantAgreement/ES/MICIN-ISCIII/IFI17-00048 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.7 2024 CARDIAC & CARDIOVASCULAR SYSTEMS 55 / 231 = 0.238 2024 Q1 T1 NUTRITION & DIETETICS 39 / 113 = 0.345 2024 Q2 T2 ENDOCRINOLOGY & METABOLISM 63 / 193 = 0.326 2024 Q2 T1 1.098 2024 Cardiology and Cardiovascular Medicine 2024 Q1 Nutrition and Dietetics 2024 Q1 Medicine (miscellaneous) 2024 Q1 Endocrinology, Diabetes and Metabolism 2024 Q2 7.0 2024 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gonzalez-Gayan, Laura Seral-Cortes, Miguel Universidad de Zaragoza (orcid)0000-0001-6899-5938 Sabroso-Lasa, Sergio Llorente-Cereza, Ma Teresa Universidad de Zaragoza Leis, Rosaura Aguilera, Concepción M. Gil-Campos, Mercedes Moreno, Luis A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Bueno-Lozano, Gloria Universidad de Zaragoza (orcid)0000-0002-0902-387X 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1011 670 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Pediatría 35, 4 (2024), 103811 [8 pp.] NMCD, Nutr. Metab. Cardiovasc. Dis. Nutrition, Metabolism and Cardiovascular Diseases 0939-4753 961270 http://zaguan.unizar.es/record/150547/files/texto_completo.pdf Versión publicada 2508165 http://zaguan.unizar.es/record/150547/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150547 articulos driver 2026-02-17-20:39:32 ARTICLE