000150594 001__ 150594
000150594 005__ 20260112133402.0
000150594 0247_ $$2doi$$a10.1007/s13105-024-01046-7
000150594 0248_ $$2sideral$$a142652
000150594 037__ $$aART-2024-142652
000150594 041__ $$aeng
000150594 100__ $$aQuesada-Vázquez, Sergio
000150594 245__ $$aPolyphenols and metabolism: from present knowledge to future challenges
000150594 260__ $$c2024
000150594 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150594 5203_ $$aA diet rich in polyphenols and other types of phytonutrients can reduce the occurrence of chronic diseases. However, a well-established cause—and—effect association has not been clearly demonstrated and several other issues will need to be fully understood before general recommendations will be carried out In the present review, some of the future challenges that the research on phenolic compounds will have to face in the next years are discussed: toxicological aspects of polyphenols and safety risk assessment; synergistic effects between different polyphenols; metabotype-based nutritional advice based on a differential gut microbial metabolism of polyphenols (precision nutrition); combination of polyphenols with other bioactive compounds; innovative formulations to improve the bioavailability of phenolic compounds; and polyphenols in sports nutrition and recovery.Other aspects related to polyphenol research that will have a boost in the next years are: polyphenol and gut microbiota crosstalk, including prebiotic effects and biotransformation of phenolic compounds into bioactive metabolites by gut microorganisms; molecular docking, molecular dynamics simulation, and quantum and molecular mechanics studies on the protein–polyphenol complexes; and polyphenol-based coating films, nanoparticles, and hydrogels to facilitate the delivery of drugs, nucleic acids and proteins.In summary, this article provides some constructive inspirations for advancing in the research of the applications, risk assessment and metabolic effects of dietary polyphenols in humans.
000150594 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000150594 590__ $$a4.3$$b2024
000150594 592__ $$a1.119$$b2024
000150594 591__ $$aPHYSIOLOGY$$b11 / 87 = 0.126$$c2024$$dQ1$$eT1
000150594 593__ $$aBiochemistry$$c2024$$dQ1
000150594 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b91 / 319 = 0.285$$c2024$$dQ2$$eT1
000150594 593__ $$aPhysiology$$c2024$$dQ1
000150594 593__ $$aMedicine (miscellaneous)$$c2024$$dQ1
000150594 594__ $$a7.5$$b2024
000150594 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150594 700__ $$aEseberri, Itziar
000150594 700__ $$0(orcid)0000-0002-7972-7119$$aLes, Francisco
000150594 700__ $$aPérez-Matute, Patricia
000150594 700__ $$aHerranz-López, María
000150594 700__ $$aAtgié, Claude
000150594 700__ $$0(orcid)0000-0002-5822-9823$$aLopez-Yus, Marta
000150594 700__ $$aAranaz, Paula
000150594 700__ $$aOteo, José A.
000150594 700__ $$aEscoté, Xavier
000150594 700__ $$0(orcid)0000-0002-1033-6152$$aLorente-Cebrian, Silvia$$uUniversidad de Zaragoza
000150594 700__ $$aRoche, Enrique
000150594 700__ $$aCourtois, Arnaud
000150594 700__ $$aLópez, Víctor
000150594 700__ $$aPortillo, María Puy
000150594 700__ $$aMilagro, Fermin I.
000150594 700__ $$aCarpéné, Christian
000150594 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000150594 773__ $$g80 (2024), 603-625$$pJ. physiol. biochem.$$tJournal of Physiology and Biochemistry$$x1138-7548
000150594 8564_ $$s1061339$$uhttps://zaguan.unizar.es/record/150594/files/texto_completo.pdf$$yVersión publicada
000150594 8564_ $$s2441438$$uhttps://zaguan.unizar.es/record/150594/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150594 909CO $$ooai:zaguan.unizar.es:150594$$particulos$$pdriver
000150594 951__ $$a2026-01-12-13:24:22
000150594 980__ $$aARTICLE