COMT genotypes correlate with cancer-related fatigue in breast cancer survivors
Romero-Elías, María ; García-González, David ; Álvarez-Bustos, Alejandro ; Garatachea, Nuria (Universidad de Zaragoza) ; Bailón, Raquel (Universidad de Zaragoza) ; Ramil, Elvira ; Maximiano, Constanza ; Cebolla-Boado, Héctor ; Ruiz-Casado, Ana
Resumen: Purpose
Cancer-related fatigue (CRF) is the most common and debilitating symptom experienced by breast cancer survivors (BCS) following treatment. The influence of genetics on CRF has been sparingly investigated. This article aims to explore the suggested impact of the catechol-O-methyltransferase (COMT) Val158Met genotypes on fatigue and to evaluate the effect on other potentially related patient-reported outcomes such as quality of life, diet, pain, or emotional facets; and also the effect on objective variables such as, heart rate variability (HRV), physical activity (PA), and biomarkers (cortisol, neutrophil-to-lymphocyte ratio, and noradrenaline).
Methods
A total of 79 BCS who had finished their treatment participated in this study. COMT genotypes were categorized as Val/Val, Val/Met, or Met/Met. PERFORM questionnaire was utilized to evaluate CRF. PA and HRV were objectively measured. The rest of the variables was assessed by questionnaires.
Results
BCS with Met/Met genotype reported higher levels of fatigue (p = 0.031), compared to those with Val/Met or Val/Val genotypes. No additional associations were found with other self-reported variables, HRV, PA, or the analysed biomarkers. The findings suggest that BCS with Met/Met genotype exhibit more elevated levels of fatigue.
Conclusion
Genetic factors could have a role in the pathogenesis of CRF. BCS with the Met/Met genotype may experience higher levels of CRF. Personalized interventions based on genetic profiling could help manage CRF more effectively.
Idioma: Inglés
DOI: 10.1080/21641846.2025.2452143
Año: 2025
Publicado en: Fatigue: Biomedicine, Health and Behavior (2025), 1-14
ISSN: 2164-1862
Tipo y forma: Artículo (PostPrint)
Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.
Fecha de embargo : 2026-01-21
Exportado de SIDERAL (2025-10-17-14:17:59)
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Cancer-related fatigue (CRF) is the most common and debilitating symptom experienced by breast cancer survivors (BCS) following treatment. The influence of genetics on CRF has been sparingly investigated. This article aims to explore the suggested impact of the catechol-O-methyltransferase (COMT) Val158Met genotypes on fatigue and to evaluate the effect on other potentially related patient-reported outcomes such as quality of life, diet, pain, or emotional facets; and also the effect on objective variables such as, heart rate variability (HRV), physical activity (PA), and biomarkers (cortisol, neutrophil-to-lymphocyte ratio, and noradrenaline).
Methods
A total of 79 BCS who had finished their treatment participated in this study. COMT genotypes were categorized as Val/Val, Val/Met, or Met/Met. PERFORM questionnaire was utilized to evaluate CRF. PA and HRV were objectively measured. The rest of the variables was assessed by questionnaires.
Results
BCS with Met/Met genotype reported higher levels of fatigue (p = 0.031), compared to those with Val/Met or Val/Val genotypes. No additional associations were found with other self-reported variables, HRV, PA, or the analysed biomarkers. The findings suggest that BCS with Met/Met genotype exhibit more elevated levels of fatigue.
Conclusion
Genetic factors could have a role in the pathogenesis of CRF. BCS with the Met/Met genotype may experience higher levels of CRF. Personalized interventions based on genetic profiling could help manage CRF more effectively.
Idioma: Inglés
DOI: 10.1080/21641846.2025.2452143
Año: 2025
Publicado en: Fatigue: Biomedicine, Health and Behavior (2025), 1-14
ISSN: 2164-1862
Tipo y forma: Artículo (PostPrint)
Área (Departamento): Área Educación Física y Depor. (Dpto. Fisiatría y Enfermería)
Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. No puede utilizar el material para una finalidad comercial. Si remezcla, transforma o crea a partir del material, no puede difundir el material modificado.Fecha de embargo : 2026-01-21
Exportado de SIDERAL (2025-10-17-14:17:59)
Enlace permanente:
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Este artículo se encuentra en las siguientes colecciones:
Artículos > Artículos por área > Teoría de la Señal y Comunicaciones
Artículos > Artículos por área > Educación Física y Deportiva
Registro creado el 2025-02-14, última modificación el 2025-10-17