doi:10.1039/d2cs00518bengGarcia-Peiro, Jose IgnacioBonet-Aleta, JavierSantamaría, JesúsHueso Martos, José LuisPlatinum Nanoplatforms: Classic Catalysts Claiming a Prominent Role in Cancer TherapyART-2022-129479Platinum nanoparticles (Pt NPs) have a well-established role as a classic heterogeneous catalyst. Also, Pt has traditionally been employed as a component of organometallic drug formulations for chemotherapy. However, a new role in cancer therapy is emerging thanks to its outstanding catalytic properties, enabling novel approaches that are surveyed in this review. Herein, we critically discuss results already obtained and attempt to ascertain future perspectives for Pt NPs as catalysts able to modify key processes taking place in the tumour microenvironment (TME). In addition, we explore relevant parameters affecting the cytotoxicity, biodistribution and clearance of Pt systems. We also analyze pros and cons in terms of biocompatibility and potential synergies that emerge from combining the catalytic capabilities of Pt with other agents such as co-catalysts, external energy sources (near-infrared light, X-ray, electric currents) and conventional therapies.2022http://zaguan.unizar.es/record/15065110.1039/d2cs00518bhttp://zaguan.unizar.es/record/150651oai:zaguan.unizar.es:150651info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCEThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCEChemical Society Reviews 51, 17 (2022), 7662-7681All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess