150651 20251017144626.0 doi 10.1039/d2cs00518b sideral 129479 ART-2022-129479 eng Garcia-Peiro, Jose Ignacio Universidad de Zaragoza (orcid)0000-0003-4874-6672 Platinum Nanoplatforms: Classic Catalysts Claiming a Prominent Role in Cancer Therapy 2022 Access copy available to the general public Unrestricted Platinum nanoparticles (Pt NPs) have a well-established role as a classic heterogeneous catalyst. Also, Pt has traditionally been employed as a component of organometallic drug formulations for chemotherapy. However, a new role in cancer therapy is emerging thanks to its outstanding catalytic properties, enabling novel approaches that are surveyed in this review. Herein, we critically discuss results already obtained and attempt to ascertain future perspectives for Pt NPs as catalysts able to modify key processes taking place in the tumour microenvironment (TME). In addition, we explore relevant parameters affecting the cytotoxicity, biodistribution and clearance of Pt systems. We also analyze pros and cons in terms of biocompatibility and potential synergies that emerge from combining the catalytic capabilities of Pt with other agents such as co-catalysts, external energy sources (near-infrared light, X-ray, electric currents) and conventional therapies. info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 46.2 2022 CHEMISTRY, MULTIDISCIPLINARY 2 / 178 = 0.011 2022 Q1 T1 15.109 2022 Chemistry (miscellaneous) 2022 Q1 81.3 2022 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Bonet-Aleta, Javier Universidad de Zaragoza (orcid)0000-0002-1791-0188 Santamaría, Jesús Universidad de Zaragoza (orcid)0000-0002-8701-9745 Hueso Martos, José Luis Universidad de Zaragoza (orcid)0000-0002-4546-4111 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 51, 17 (2022), 7662-7681 Chem. Soc. rev. Chemical Society Reviews 0306-0012 1836928 http://zaguan.unizar.es/record/150651/files/texto_completo.pdf Postprint 2217933 http://zaguan.unizar.es/record/150651/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:150651 articulos driver 2025-10-17-14:24:13 ARTICLE