000150677 001__ 150677
000150677 005__ 20251017144640.0
000150677 0247_ $$2doi$$a10.1016/j.diagmicrobio.2025.116718
000150677 0248_ $$2sideral$$a142815
000150677 037__ $$aART-2025-142815
000150677 041__ $$aeng
000150677 100__ $$0(orcid)0000-0002-6979-9397$$ade Escalante Yangüela, Begoña
000150677 245__ $$aSuccessful maintenance therapy with moxifloxacin for disseminated nocardiosis caused by Nocardia farcinica in a patient with Cushing's syndrome
000150677 260__ $$c2025
000150677 5203_ $$aNocardia species are aerobic, Gram-positive actinomycetes often causing opportunistic infections, particularly in immunocompromised hosts. Nocardia farcinica is notable for disseminated nocardiosis (DN), frequently involving the lungs and central nervous system (CNS). Cushing's syndrome (CS), characterized by hypercortisolemia, further predisposes patients to severe infections.
We report a 73-year-old woman with ACTH-dependent CS due to a pituitary adenoma who developed DN with pleuropulmonary, CNS, and gluteal abscesses. Diagnosis was confirmed through cultures and MALDI-TOF MS, identifying N. farcinica. Resistance to standard antibiotics required a tailored regimen, including imipenem, amikacin, and moxifloxacin, alongside surgical management of abscesses and the adenoma.
This case emphasizes the importance of rapid diagnostic methods and individualized therapies in managing DN with CS, a rare but severe combination. It highlights the need for vigilance in high-risk patients and contributes valuable insights for optimizing outcomes in such complex cases.
000150677 540__ $$9info:eu-repo/semantics/closedAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000150677 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150677 700__ $$aLigero López, Jorge$$uUniversidad de Zaragoza
000150677 700__ $$aVenegas Robles, Alejandro
000150677 700__ $$aUrdaniz Borque, Rosana
000150677 700__ $$aVallejo Grijalba, Juan
000150677 700__ $$aBandrés Nivela, Orosia
000150677 700__ $$aJuan Bañón, José Luis
000150677 700__ $$aBeltrán Rosel, Antonio$$uUniversidad de Zaragoza
000150677 7102_ $$11011$$2660$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Parasitología
000150677 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000150677 773__ $$g111, 3 (2025), 116718 [6 pp.]$$pDiagn. microbiol. infect. dis.$$tDiagnostic Microbiology and Infectious Disease$$x0732-8893
000150677 8564_ $$s5335274$$uhttps://zaguan.unizar.es/record/150677/files/texto_completo.pdf$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-01-30
000150677 8564_ $$s2353041$$uhttps://zaguan.unizar.es/record/150677/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada$$zinfo:eu-repo/date/embargoEnd/2026-01-30
000150677 909CO $$ooai:zaguan.unizar.es:150677$$particulos$$pdriver
000150677 951__ $$a2025-10-17-14:31:32
000150677 980__ $$aARTICLE