150694 20251017144641.0 doi 10.1016/j.lanepe.2025.101220 sideral 142863 ART-2025-142863 eng Peñalva, Germán Burden of bacterial antimicrobial resistance among hospitalised patients in Spain: findings from three nationwide prospective studies 2025 Access copy available to the general public Unrestricted Background: Assessing the burden of antimicrobial resistance is essential to determine the magnitude of this problem and to set its priority. We aimed to estimate the burden of disease caused by multidrug-resistant microorganisms (MDRO) in hospitalised patients in Spain. Methods: Three prospective nationwide studies were conducted in 2018, 2019 and 2023. All patients with a new diagnosis of infection with any of 10 selected MDROs plus Clostridioides difficile during the study period (one week in 2018 and 2019 and two weeks in 2023) were included. Patient demographic, and clinical outcomes were analysed, including incidence, crude all-cause 30-day mortality and years of life lost (YLL). These results were used to calculate weighted and seasonally adjusted annual estimates for the whole country. info:eu-repo/semantics/openAccess by-nc-nd https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cantón, Rafael Pérez-Rodríguez, María Teresa González-López, Juan José Rodríguez-Baño, Jesús Barrio-Tofiño, Ester del Kirkegaard-Biosca, Cristina Sánchez-Romero, Isabel Gutiérrez-Villanueva, Andrea Marrodán-Ciordia, Teresa Guerra-Laso, José Manuel Rosario-Quintana, Cristóbal del Suárez-Hormiga, Laura Cámara, Jordi Puig-Asensio, Mireia Heredero, Eva Sepúlveda, María Antonia Rodríguez-Díaz, Juan Carlos Merino, Esperanza Cercenado, Emilia Villa, Sofia de la Siller, María Arnaiz, Francisco Seral, Cristina Universidad de Zaragoza (orcid)0000-0002-9742-1463 Lepe, José Antonio Cisneros, José Miguel Paño-Pardo, José Ramón Universidad de Zaragoza (orcid)0000-0002-9600-8116 Castiillo García, Francisco Universidad de Zaragoza (orcid)0000-0002-2519-701X 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 51 (2025), 101220 [13 pp.] The Lancet Regional Health - Europe 2666-7762 328135 http://zaguan.unizar.es/record/150694/files/texto_completo.pdf Versión publicada 2480445 http://zaguan.unizar.es/record/150694/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150694 articulos driver 2025-10-17-14:31:51 ARTICLE