000150702 001__ 150702
000150702 005__ 20250214153850.0
000150702 0247_ $$2doi$$a10.1038/s42003-024-07314-y
000150702 0248_ $$2sideral$$a142761
000150702 037__ $$aART-2025-142761
000150702 041__ $$aeng
000150702 100__ $$aCabrera-Alarcon, José Luis
000150702 245__ $$aShaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
000150702 260__ $$c2025
000150702 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150702 5203_ $$aThe frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.
000150702 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/CB16-10-00282$$9info:eu-repo/grantAgreement/ES/MICINN/CEX2020-001041-S$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-127988OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/PID2022-141527OB-I00$$9info:eu-repo/grantAgreement/ES/MICINN/TED2021-131611B-I00
000150702 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000150702 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150702 700__ $$aCruz, Raquel
000150702 700__ $$aRosa-Moreno, Marina
000150702 700__ $$0(orcid)0000-0002-4703-6620$$aLatorre-Pellicer, Ana$$uUniversidad de Zaragoza
000150702 700__ $$ade Almeida, Silvia Diz
000150702 700__ $$aAbellan, Javier
000150702 700__ $$aAcosta-Isaac, René
000150702 700__ $$aAguado, Jose María
000150702 700__ $$aAguilar, Carlos
000150702 700__ $$aAguilera-Albesa, Sergio
000150702 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000150702 773__ $$g8, 1 (2025), [12 pp.]$$tCommunications Biology$$x2399-3642
000150702 8564_ $$s1202314$$uhttps://zaguan.unizar.es/record/150702/files/texto_completo.pdf$$yVersión publicada
000150702 8564_ $$s2906905$$uhttps://zaguan.unizar.es/record/150702/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150702 909CO $$ooai:zaguan.unizar.es:150702$$particulos$$pdriver
000150702 951__ $$a2025-02-14-14:02:57
000150702 980__ $$aARTICLE