000150715 001__ 150715
000150715 005__ 20251017144642.0
000150715 0247_ $$2doi$$a10.1016/j.domaniend.2025.106916
000150715 0248_ $$2sideral$$a142871
000150715 037__ $$aART-2025-142871
000150715 041__ $$aeng
000150715 100__ $$0(orcid)0000-0003-1997-4262$$aCasao, Adriana$$uUniversidad de Zaragoza
000150715 245__ $$aFrom spermatogenesis to fertilisation: the role of melatonin on ram spermatozoa
000150715 260__ $$c2025
000150715 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150715 5203_ $$aThis review presents recent findings on the effect of melatonin on ram spermatozoa. This hormone regulates seasonal reproduction in the ovine species through the hypothalamic-pituitary-gonadal axis, but it also exerts direct effects on spermatogenesis, seminal quality and fertility. In the testis, melatonin stimulates blood flow to this organ, but it also appears to be involved in the differentiation of spermatogonial stem cells and the secretion of testosterone through the MT1 and MT2 receptors. In the epididymis, this hormone modulates sperm maturation and the secretory activity of epidydimal epithelial cells. In addition, the antioxidant activity of melatonin may protect spermatozoa from oxidative damage during their formation in the testis and their maturation in the epididymis. After ejaculation, the melatonin present in seminal plasma may also protect sperm from oxidative damage and premature capacitation and may improve seminal quality. Finally, once the sperm begins its transit through the female genital tract, melatonin may modulate sperm capacitation. Thus, melatonin could have a bimodal activity in ram sperm capacitation, so high concentrations, such as those in seminal plasma, have a decapacitating effect. In contrast, low concentrations, such as those present in the female reproductive tract, may promote it, likely through interaction with MT2 receptors. In addition, melatonin could also be involved in chemotaxis and fertilisation, although further studies are needed to elucidate the specific role of melatonin in these processes. Finally, the effect of latitude and melatonin receptor gene polymorphisms in ram reproduction is also discussed.
000150715 540__ $$9info:eu-repo/semantics/embargoedAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
000150715 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000150715 700__ $$0(orcid)0000-0002-4670-3735$$aPeña-Delgado, Victoria
000150715 700__ $$0(orcid)0000-0002-2312-6402$$aPérez-Pe, Rosaura$$uUniversidad de Zaragoza
000150715 7102_ $$11002$$2819$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Zoología
000150715 773__ $$g91 (2025), 106916 [8 pp.]$$pDomest. anim. endocrinol.$$tDomestic Animal Endocrinology$$x0739-7240
000150715 8564_ $$s1491066$$uhttps://zaguan.unizar.es/record/150715/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-01-14
000150715 8564_ $$s2469327$$uhttps://zaguan.unizar.es/record/150715/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-01-14
000150715 909CO $$ooai:zaguan.unizar.es:150715$$particulos$$pdriver
000150715 951__ $$a2025-10-17-14:32:28
000150715 980__ $$aARTICLE