000150743 001__ 150743
000150743 005__ 20250214153851.0
000150743 0247_ $$2doi$$a10.1016/j.psyneuen.2025.107358
000150743 0248_ $$2sideral$$a142813
000150743 037__ $$aART-2025-142813
000150743 041__ $$aeng
000150743 100__ $$aMartino, Pablo
000150743 245__ $$aStress and telomere length in leukocytes: Investigating the role of GABRA6 gene polymorphism and cortisol
000150743 260__ $$c2025
000150743 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150743 5203_ $$aTelomere length (TL) is considered a biomarker of aging, and short TL in leukocytes is related to age and stress-related health problems. Cumulative lifetime stress exposure has also been associated with shorter TL and age-related health problems, but the mechanisms are not well understood. We tested in 108 individuals whether shorter TL in leukocytes is observed in individuals with the GABRA6 TT genotype, which has been associated with dysregulation of hypothalamic-pituitary-adrenal axis activity (the main biological stress system) compared to the CC genotype. We also investigated if individuals carrying the TT genotype show higher stress-induced and diurnal cortisol secretion and if cortisol explains the interindividual variability in TL. The analysis pipeline of this study was pre-registered, and the results showed that GABRA6 TT carriers had shorter TL in CD8+CD28+ cells (Bonferroni corrected). In contrast to previous studies, no differences between groups in cortisol secretion were observed, and TL and cortisol did not show significant associations. This study shows, for the first time, shorter TL in CD8+CD28+ cells in TT carriers for GABRA6 compared to CC carriers, suggesting accelerated cellular aging. Although this difference could be linked to an increased susceptibility to stress in the TT carriers, this could not be attributed to the direct influence of cortisol, suggesting the involvement of other mechanisms.
000150743 536__ $$9info:eu-repo/grantAgreement/ES/DGA/S31-23R$$9info:eu-repo/grantAgreement/ES/AEI/MICNN/PID2021–125945OB-I00
000150743 540__ $$9info:eu-repo/semantics/embargoedAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000150743 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000150743 700__ $$aPerez-Alarcón, Mario
000150743 700__ $$aDeconinck, Luna
000150743 700__ $$aDe Raedt, Rudi
000150743 700__ $$aVanderhasselt, Marie-Anne
000150743 700__ $$aKozusznik, Malgorzata W.
000150743 700__ $$aKooy, Frank
000150743 700__ $$0(orcid)0000-0003-3920-1099$$aHidalgo, Vanesa$$uUniversidad de Zaragoza
000150743 700__ $$aVenero, César
000150743 700__ $$aSalvador, Alicia
000150743 700__ $$aBaeken, Chris
000150743 700__ $$aPulopulos, Matias M.
000150743 7102_ $$14009$$2725$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicobiología
000150743 773__ $$g173 (2025), 107358 [10 pp.]$$pPsychoneuroendocrinology$$tPSYCHONEUROENDOCRINOLOGY$$x0306-4530
000150743 8564_ $$s978926$$uhttps://zaguan.unizar.es/record/150743/files/texto_completo.pdf$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-01-17
000150743 8564_ $$s1600497$$uhttps://zaguan.unizar.es/record/150743/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint$$zinfo:eu-repo/date/embargoEnd/2026-01-17
000150743 909CO $$ooai:zaguan.unizar.es:150743$$particulos$$pdriver
000150743 951__ $$a2025-02-14-14:03:48
000150743 980__ $$aARTICLE