| Home > Articles > Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology > MARC |
000150761 001__ 150761 000150761 005__ 20251017144650.0 000150761 0247_ $$2doi$$a10.1016/j.tcb.2024.12.014 000150761 0248_ $$2sideral$$a142856 000150761 037__ $$aART-2025-142856 000150761 041__ $$aeng 000150761 100__ $$aKeshavanarayana, Pradeep 000150761 245__ $$aLeveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology 000150761 260__ $$c2025 000150761 5060_ $$aAccess copy available to the general public$$fUnrestricted 000150761 5203_ $$aEndothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Computational models have emerged as powerful tools to elucidate how mechanical cues impact the behavior of these monolayers in health and disease. Herein, the importance of mechanics in regulating ENC and EPC monolayer behavior is established, highlighting similarities and differences in various biological contexts. Concurrently, computational approaches and their importance in accelerating mechanobiology studies are discussed, emphasizing their limitations and suggesting future directions. The aim is to inspire further synergies between cell biologists and modelers, which are crucial for accelerating cell mechanobiology research. 000150761 536__ $$9info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101018587-ICoMICS$$9info:eu-repo/grantAgreement/ES/MCIU/FPU20-05274$$9info:eu-repo/grantAgreement/ES/MICINN/PID2021-124271OB-I00 000150761 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es 000150761 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000150761 700__ $$0(orcid)0000-0003-4617-8130$$aAparicio-Yuste, Raul 000150761 700__ $$aSpill, Fabian 000150761 700__ $$0(orcid)0000-0002-1878-8997$$aGómez-Benito, María José$$uUniversidad de Zaragoza 000150761 700__ $$aBastounis, Effie E. 000150761 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000150761 773__ $$g(2025), [15 pp.]$$pTrends cell biol.$$tTRENDS IN CELL BIOLOGY$$x0962-8924 000150761 8564_ $$s2156717$$uhttps://zaguan.unizar.es/record/150761/files/texto_completo.pdf$$yVersión publicada 000150761 8564_ $$s3011850$$uhttps://zaguan.unizar.es/record/150761/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000150761 909CO $$ooai:zaguan.unizar.es:150761$$particulos$$pdriver 000150761 951__ $$a2025-10-17-14:36:03 000150761 980__ $$aARTICLE
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