150761 20251017144650.0 doi 10.1016/j.tcb.2024.12.014 sideral 142856 ART-2025-142856 eng Keshavanarayana, Pradeep Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology 2025 Access copy available to the general public Unrestricted Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Computational models have emerged as powerful tools to elucidate how mechanical cues impact the behavior of these monolayers in health and disease. Herein, the importance of mechanics in regulating ENC and EPC monolayer behavior is established, highlighting similarities and differences in various biological contexts. Concurrently, computational approaches and their importance in accelerating mechanobiology studies are discussed, emphasizing their limitations and suggesting future directions. The aim is to inspire further synergies between cell biologists and modelers, which are crucial for accelerating cell mechanobiology research. info:eu-repo/grantAgreement/EC/H2020/101018587/EU/Individual and Collective Migration of the Immune Cellular System/ICoMICS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 101018587-ICoMICS info:eu-repo/grantAgreement/ES/MCIU/FPU20-05274 info:eu-repo/grantAgreement/ES/MICINN/PID2021-124271OB-I00 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aparicio-Yuste, Raul (orcid)0000-0003-4617-8130 Spill, Fabian Gómez-Benito, María José Universidad de Zaragoza (orcid)0000-0002-1878-8997 Bastounis, Effie E. 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. (2025), [15 pp.] Trends cell biol. TRENDS IN CELL BIOLOGY 0962-8924 2156717 http://zaguan.unizar.es/record/150761/files/texto_completo.pdf Versión publicada 3011850 http://zaguan.unizar.es/record/150761/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150761 articulos driver 2025-10-17-14:36:03 ARTICLE