000150771 001__ 150771
000150771 005__ 20251017144651.0
000150771 0247_ $$2doi$$a10.1002/anie.202424037
000150771 0248_ $$2sideral$$a142750
000150771 037__ $$aART-2025-142750
000150771 041__ $$aeng
000150771 100__ $$0(orcid)0000-0003-4874-6672$$aGarcía-Peiró, José I.$$uUniversidad de Zaragoza
000150771 245__ $$aDendritic platinum nanoparticles shielded by Pt-S PEGylation as intracellular reactors for bioorthogonal uncaging Chemistry
000150771 260__ $$c2025
000150771 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150771 5203_ $$aBeyond their classical role as cytotoxics, Platinum (Pt) coordination complexes recently joined the selected group of transition metals capable of performing bioorthogonal reactions in living environments. To minimize their reactivity towards nucleophiles, which limit their catalytic performance, we investigated the use of Pt(0) with different forms, sizes and surface functionalization. We report herein the development of PEGylated Pt nanodendrites with the capacity to activate prodyes and prodrugs in cell culture and in vivo. Their dendritic morphology together with their surface shielding through Pt‐S‐bonded PEGylation synergistically contributed to create catalytic nanoreactors compatible with the highly‐crowded and reductive environment of the cell cytoplasm, thereby facilitating in situ bioorthogonal drug uncaging in cancer cells in 2D and 3D culture, including in microfluidic systems, and xenografted in zebrafish.
000150771 536__ $$9info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S$$9info:eu-repo/grantAgreement/EC/HORIZON EUROPE/841990/EU/Gold-Functionalized Devices and Engineered Nanoparticles: Bioorthogonal Tools for Unprecedented Biomedical Applications/GOLDEN$$9info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE
000150771 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000150771 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150771 700__ $$0(orcid)0000-0001-5835-1223$$aOrtega-Liébana, M. Carmen
000150771 700__ $$aAdam, Catherine
000150771 700__ $$aLorente-Macías, Álvaro
000150771 700__ $$aTravnickova, Jana
000150771 700__ $$aPatton, E. Elizabeth
000150771 700__ $$aGuerrero-López, Paula$$uUniversidad de Zaragoza
000150771 700__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, J. Manuel$$uUniversidad de Zaragoza
000150771 700__ $$0(orcid)0000-0002-4546-4111$$aHueso, José L.$$uUniversidad de Zaragoza
000150771 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaría, Jesús$$uUniversidad de Zaragoza
000150771 700__ $$aUnciti-Broceta, Asier
000150771 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000150771 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000150771 7102_ $$15005$$2790$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Tecnologi. Medio Ambiente
000150771 773__ $$g64, 14 (2025), e202424037 [10 pp.]$$pAngew. Chem. (Int. ed.)$$tAngewandte Chemie (International ed.)$$x1433-7851
000150771 8564_ $$s520463$$uhttps://zaguan.unizar.es/record/150771/files/texto_completo.pdf$$yVersión publicada
000150771 8564_ $$s2529144$$uhttps://zaguan.unizar.es/record/150771/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150771 909CO $$ooai:zaguan.unizar.es:150771$$particulos$$pdriver
000150771 951__ $$a2025-10-17-14:36:21
000150771 980__ $$aARTICLE