150771 20260126150157.0 doi 10.1002/anie.202424037 sideral 142750 ART-2025-142750 eng García-Peiró, José I. Universidad de Zaragoza (orcid)0000-0003-4874-6672 Dendritic platinum nanoparticles shielded by Pt-S PEGylation as intracellular reactors for bioorthogonal uncaging Chemistry 2025 Access copy available to the general public Unrestricted Beyond their classical role as cytotoxics, Platinum (Pt) coordination complexes recently joined the selected group of transition metals capable of performing bioorthogonal reactions in living environments. To minimize their reactivity towards nucleophiles, which limit their catalytic performance, we investigated the use of Pt(0) with different forms, sizes and surface functionalization. We report herein the development of PEGylated Pt nanodendrites with the capacity to activate prodyes and prodrugs in cell culture and in vivo. Their dendritic morphology together with their surface shielding through Pt‐S‐bonded PEGylation synergistically contributed to create catalytic nanoreactors compatible with the highly‐crowded and reductive environment of the cell cytoplasm, thereby facilitating in situ bioorthogonal drug uncaging in cancer cells in 2D and 3D culture, including in microfluidic systems, and xenografted in zebrafish. info:eu-repo/grantAgreement/ES/AEI/CEX2023-001286-S info:eu-repo/grantAgreement/EC/HORIZON EUROPE/841990/EU/Gold-Functionalized Devices and Engineered Nanoparticles: Bioorthogonal Tools for Unprecedented Biomedical Applications/GOLDEN info:eu-repo/grantAgreement/EC/H2020/742684/EU/Catalytic Dual-Function Devices Against Cancer/CADENCE This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 742684-CADENCE info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ortega-Liébana, M. Carmen (orcid)0000-0001-5835-1223 Adam, Catherine Lorente-Macías, Álvaro Travnickova, Jana Patton, E. Elizabeth Guerrero-López, Paula Universidad de Zaragoza (orcid)0000-0003-3661-7718 García-Aznar, J. Manuel Universidad de Zaragoza (orcid)0000-0002-9864-7683 Hueso, José L. Universidad de Zaragoza (orcid)0000-0002-4546-4111 Santamaría, Jesús Universidad de Zaragoza (orcid)0000-0002-8701-9745 Unciti-Broceta, Asier 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 5005 790 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Tecnologi. Medio Ambiente 64, 14 (2025), e202424037 [10 pp.] Angew. Chem. (Int. ed.) Angewandte Chemie (International ed.) 1433-7851 520463 http://zaguan.unizar.es/record/150771/files/texto_completo.pdf Versión publicada 2529144 http://zaguan.unizar.es/record/150771/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150771 articulos driver 2026-01-26-14:59:59 ARTICLE