150948 20251017144548.0 doi 10.1080/14767058.2019.1628942 sideral 112024 ART-2021-112024 eng Gonzalez Ballano, Isabel Pregestational body mass index, trimester-specific weight gain and total gestational weight gain: how do they influence perinatal outcomes? 2021 Access copy available to the general public Unrestricted Objective: To investigate the association between pregestational body mass index (BMI), total gestational weight gain (GWG) and/or trimester-specific weight gain (GWGT) with adverse maternal or perinatal outcomes (AMPOs). Material and methods: Maternal clinical characteristics and pregnancy and perinatal outcomes were used to predict AMPOs. The predictive ability of BMI, GWG or GWGT for AMPOs was analyzed using the area under the curve (AUC). Logistic regression models in a univariate and multivariate analysis were performed to estimate the odds ratios (OR) and 95% confidence intervals (CI) to predict maternal outcomes (pregnancy induced hypertension, preeclampsia or gestational diabetes mellitus) and perinatal outcomes (small for gestational age, large for gestational age, 5-min Apgar score, admission to neonatal intensive care unit or umbilical cord pH < 7.15). Results: Women with AMPOs (n = 293) were younger with higher rate of nulliparity (p < 0.001) and with lower height (p = 0.018) as compared to controls (n = 134). In the univariate study, GWGT in third trimester was associated with double risk of pregnancy induced hypertension (OR 2.00; 95% CI, 1.01–3.97). Nonetheless, third-trimester GWG and total GWG have a negative relationship with gestational diabetes mellitus OR 0.32 (95% CI, 0.18–0.58) and OR 0.35 (95% CI, 0.21–0.59), respectively. Women with greater overall and in second trimester GWG have lower risk of having SGA neonates, OR 0.62 (95% CI, 0.39–0.98) and OR 0.60 (95% CI, 0.37–0.98), respectively. In the multivariate study, pregestational BMI is strongly related to the development of preeclampsia and the area under the curve (AUC) of the combination of pregestational BMI and total weight gain was 0.832 (95% CI, 0.63–0.81) for preeclampsia and 0.719 (95% CI, 0.71–0.94) for gestational diabetes mellitus. Conclusion: Our results suggest than timing of gestational weight gain influence in maternal and perinatal outcomes. Pregestational BMI is a determinant of preeclampsia, maternal weight gain in the third trimester is a determinant of pregnancy induced hypertension and the increase in total GWG reduces the risk of gestational diabetes mellitus and small for gestational age. info:eu-repo/semantics/openAccess by-nc https://creativecommons.org/licenses/by-nc/4.0/deed.es 2.323 2021 OBSTETRICS & GYNECOLOGY 61 / 85 = 0.718 2021 Q3 T3 0.61 2021 Pediatrics, Perinatology and Child Health 2021 Q2 Obstetrics and Gynecology 2021 Q2 4.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Savirón Cornudella, Ricardo Universidad de Zaragoza (orcid)0000-0001-9585-0187 Esteban Escaño, Luis Mariano (orcid)0000-0002-3007-302X Sanz Saiz, Gerardo Universidad de Zaragoza (orcid)0000-0002-6474-2252 Castán Mateo, Sergio Universidad de Zaragoza (orcid)0000-0002-9048-121X 2007 265 Universidad de Zaragoza Dpto. Métodos Estadísticos Área Estadís. Investig. Opera. 1003 027 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Anatom.Embriol.Humana 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 34, 8 (2021), 1207-1214 J. matern.-fetal neonatal med. Journal of Maternal-Fetal and Neonatal Medicine 1476-7058 1494899 http://zaguan.unizar.es/record/150948/files/texto_completo.pdf Versión publicada 1061259 http://zaguan.unizar.es/record/150948/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150948 articulos driver 2025-10-17-14:10:35 ARTICLE