000150988 001__ 150988
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000150988 0247_ $$2doi$$a10.1021/acs.orglett.1c00470
000150988 0248_ $$2sideral$$a124171
000150988 037__ $$aART-2021-124171
000150988 041__ $$aeng
000150988 100__ $$aOrtega, A.
000150988 245__ $$aBrønsted Acid Catalyzed (4 + 2) Cyclocondensation of 3-Substituted Indoles with Donor-Acceptor Cyclopropanes
000150988 260__ $$c2021
000150988 5060_ $$aAccess copy available to the general public$$fUnrestricted
000150988 5203_ $$aAcylcyclopropanes are employed as useful donor-acceptor cyclopropanes that undergo formal (4 + 2) cyclocondensation with N-unprotected 3-substituted indoles in the presence of a Brønsted acid catalyst. The reaction involves the simultaneous alkylation of both the N and C-2 positions of the indole and provides access to the 8, 9-dihydropyrido[1, 2-a]indole scaffold that is the central core of several biologically relevant indole alkaloids in excellent yields and good selectivities.
000150988 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E34-20R$$9info:eu-repo/grantAgreement/ES/MINECO/PID2019-104090RB-100$$9info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-76155-R
000150988 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttps://creativecommons.org/licenses/by/4.0/deed.es
000150988 590__ $$a6.072$$b2021
000150988 591__ $$aCHEMISTRY, ORGANIC$$b4 / 56 = 0.071$$c2021$$dQ1$$eT1
000150988 592__ $$a1.669$$b2021
000150988 593__ $$aOrganic Chemistry$$c2021$$dQ1
000150988 593__ $$aBiochemistry$$c2021$$dQ1
000150988 594__ $$a10.4$$b2021
000150988 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000150988 700__ $$aUria, U.
000150988 700__ $$0(orcid)0000-0003-3433-6701$$aTejero, T.$$uUniversidad de Zaragoza
000150988 700__ $$aPrieto, L.
000150988 700__ $$aReyes, E.
000150988 700__ $$0(orcid)0000-0002-2202-3460$$aMerino, P.$$uUniversidad de Zaragoza
000150988 700__ $$aVicario, J.L.
000150988 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000150988 773__ $$g23, 6 (2021), 2326–2331$$pOrg. lett.$$tORGANIC LETTERS$$x1523-7060
000150988 8564_ $$s1375185$$uhttps://zaguan.unizar.es/record/150988/files/texto_completo.pdf$$yVersión publicada
000150988 8564_ $$s2880776$$uhttps://zaguan.unizar.es/record/150988/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000150988 909CO $$ooai:zaguan.unizar.es:150988$$particulos$$pdriver
000150988 951__ $$a2025-10-17-14:17:28
000150988 980__ $$aARTICLE