150988 20251017144611.0 doi 10.1021/acs.orglett.1c00470 sideral 124171 ART-2021-124171 eng Ortega, A. Brønsted Acid Catalyzed (4 + 2) Cyclocondensation of 3-Substituted Indoles with Donor-Acceptor Cyclopropanes 2021 Access copy available to the general public Unrestricted Acylcyclopropanes are employed as useful donor-acceptor cyclopropanes that undergo formal (4 + 2) cyclocondensation with N-unprotected 3-substituted indoles in the presence of a Brønsted acid catalyst. The reaction involves the simultaneous alkylation of both the N and C-2 positions of the indole and provides access to the 8, 9-dihydropyrido[1, 2-a]indole scaffold that is the central core of several biologically relevant indole alkaloids in excellent yields and good selectivities. info:eu-repo/grantAgreement/ES/DGA/E34-20R info:eu-repo/grantAgreement/ES/MINECO/PID2019-104090RB-100 info:eu-repo/grantAgreement/ES/MINECO-FEDER/CTQ2016-76155-R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 6.072 2021 CHEMISTRY, ORGANIC 4 / 56 = 0.071 2021 Q1 T1 1.669 2021 Organic Chemistry 2021 Q1 Biochemistry 2021 Q1 10.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Uria, U. Tejero, T. Universidad de Zaragoza (orcid)0000-0003-3433-6701 Prieto, L. Reyes, E. Merino, P. Universidad de Zaragoza (orcid)0000-0002-2202-3460 Vicario, J.L. 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 23, 6 (2021), 2326–2331 Org. lett. ORGANIC LETTERS 1523-7060 1375185 http://zaguan.unizar.es/record/150988/files/texto_completo.pdf Versión publicada 2880776 http://zaguan.unizar.es/record/150988/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:150988 articulos driver 2025-10-17-14:17:28 ARTICLE