000151004 001__ 151004 000151004 005__ 20251017144616.0 000151004 0247_ $$2doi$$a10.1016/j.neulet.2021.136164 000151004 0248_ $$2sideral$$a126067 000151004 037__ $$aART-2021-126067 000151004 041__ $$aeng 000151004 100__ $$aFugazzotto, F. 000151004 245__ $$aHypericum perforatum L. prevents the acquisition of and promotes resilience against stress-induced reinstatement of the conditioned place preference induced by cocaine 000151004 260__ $$c2021 000151004 5060_ $$aAccess copy available to the general public$$fUnrestricted 000151004 5203_ $$aCocaine use disorder is a serious problem worldwide, and there are no approved medications for its treatment. A novel approach to the treatment of drug addiction is the use of natural products, and, in this context, preclinical evidence suggests that Hypericum perforatum L. (Hypericum) is effective against alcohol and other substance use disorders. We hypothesised that Hypericum could also be useful as a treatment for cocaine use disorder, and so we set out to test its effectiveness in a mice model of cocaine addiction. In the first experiment we evaluated its effects on the acquisition of cocaine-induced conditioned place preference (CPP). Adult male mice were conditioned with cocaine (25 mg/kg), cocaine with Hypericum (75, 150 or 300 mg/kg) or the plant extract alone (300 mg/kg). In the second experiment, we tested the effects of Hypericum on stress-induced reinstatement of cocaine CPP. All the mice were conditioned with cocaine (25 mg/kg) and, after extinction of CPP, the reinstating effects of social defeat (alone or with 75, 150 or 300 mg/kg of Hypericum) were evaluated. All the doses of Hypericum prevented the acquisition of cocaine-induced CPP. Furthermore, the plant extract dose-dependently reduced the reinstating effects of social defeat. Therefore, Hypericum is effective in reducing the rewarding effects of cocaine and prevents the stress-induced reinstatement of cocaine CPP in mice. The mechanisms underlying these positive effects of Hypericum perforatum L. need to be determined by future research. Our results endorse Hypericum as a natural treatment for cocaine dependence. 000151004 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/PSI2017-83023 000151004 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es 000151004 590__ $$a3.197$$b2021 000151004 591__ $$aNEUROSCIENCES$$b182 / 275 = 0.662$$c2021$$dQ3$$eT3 000151004 592__ $$a0.783$$b2021 000151004 593__ $$aNeuroscience (miscellaneous)$$c2021$$dQ2 000151004 594__ $$a5.1$$b2021 000151004 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000151004 700__ $$aOcchiuto, F. 000151004 700__ $$aGarcia-Pardo, M.P.$$uUniversidad de Zaragoza 000151004 700__ $$aAguilar, M.A. 000151004 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac 000151004 773__ $$g762 (2021), 136164 [5 pp.]$$pNeurosci. lett.$$tNEUROSCIENCE LETTERS$$x0304-3940 000151004 8564_ $$s527093$$uhttps://zaguan.unizar.es/record/151004/files/texto_completo.pdf$$yVersión publicada 000151004 8564_ $$s2421863$$uhttps://zaguan.unizar.es/record/151004/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000151004 909CO $$ooai:zaguan.unizar.es:151004$$particulos$$pdriver 000151004 951__ $$a2025-10-17-14:19:17 000151004 980__ $$aARTICLE