151006 20251017144616.0 doi 10.1021/acs.jafc.1c02845 sideral 126071 ART-2021-126071 eng Song, X-C. Discovery and Characterization of Phenolic Compounds in Bearberry (Arctostaphylos uva-ursi) Leaves Using Liquid Chromatography-Ion Mobility-High-Resolution Mass Spectrometry 2021 Access copy available to the general public Unrestricted The characterization and quantification of phenolic compounds in bearberry leaves were performed using hyphenated ion mobility spectroscopy (IMS) and a quadrupole time-of-flight mass spectrometer. A higher identification confidence level was obtained by comparing the measured collision cross section ((CCSN2)-C-TW) with predicted values using a machine learning algorithm. A total of 88 compounds were identified, including 14 arbutin derivatives, 33 hydrolyzable tannins, 6 flavanols, 26 flavonols, 9 saccharide derivatives, and glycosidic compounds. Those most reliably reproduced in all samples were quantified against respective standards. Arbutin (47-107 mg/g), 1, 2, 3, 4, 6-pentagalloylglucose (6.6-12.9 mg/g), and quercetin 3-galactoside/quercetin 3-glucoside (2.7-5.7 mg/g) were the most abundant phenolic components in the leaves. Quinic acid and ellagic acid were also detected at relatively high concentrations. The antioxidant activity of the most abundant compounds was evaluated. A critical view of the advantages and limitations of traveling wave IMS and CCS for the discovery of natural products is given. info:eu-repo/grantAgreement/ES/AEI/RTI2018-097805-B-I00 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 5.895 2021 CHEMISTRY, APPLIED 14 / 72 = 0.194 2021 Q1 T1 AGRICULTURE, MULTIDISCIPLINARY 6 / 59 = 0.102 2021 Q1 T1 FOOD SCIENCE & TECHNOLOGY 32 / 144 = 0.222 2021 Q1 T1 1.018 2021 Chemistry (miscellaneous) 2021 Q1 Agricultural and Biological Sciences (miscellaneous) 2021 Q1 8.6 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Canellas, E. Universidad de Zaragoza (orcid)0000-0003-2638-9221 Dreolin, N. Nerin, C. Universidad de Zaragoza (orcid)0000-0003-2685-5739 Goshawk, J. 2009 750 Universidad de Zaragoza Dpto. Química Analítica Área Química Analítica 69, 37 (2021), 10856-10868 J. agric. food chem. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 0021-8561 2428601 http://zaguan.unizar.es/record/151006/files/texto_completo.pdf Versión publicada 3289501 http://zaguan.unizar.es/record/151006/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151006 articulos driver 2025-10-17-14:19:20 ARTICLE