000151018 001__ 151018
000151018 005__ 20250221105702.0
000151018 0247_ $$2doi$$a10.1038/s41598-021-89992-w
000151018 0248_ $$2sideral$$a125453
000151018 037__ $$aART-2021-125453
000151018 041__ $$aeng
000151018 100__ $$0(orcid)0000-0003-2710-1875$$aOrduna-Hospital, Elvira$$uUniversidad de Zaragoza
000151018 245__ $$aChanges in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
000151018 260__ $$c2021
000151018 5060_ $$aAccess copy available to the general public$$fUnrestricted
000151018 5203_ $$aTo evaluate changes in inner retinal layer (IRL) thicknesses in patients with type 1 diabetes mellitus (DM1) with no diabetic retinopathy (DR) using two different optical coherence tomography (OCT) devices. Ninety DM1 and 60 healthy eyes were evaluated using spectral domain (SD)-OCT and swept source (SS)-OCT to measure changes in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and inner nuclear layer (INL) thicknesses in all Early Treatment of Diabetic Retinopathy Study (ETDRS) macular areas. Functional tests were performed in both groups, including ETDRS with 100, 2.5 and 1.25% contrast, and color vision. The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control groups, respectively. Visual acuity (VA) with ETDRS 1.25% was lower in the DM1 patients. Both ETDRS 2.5% and color vision were lower in the DM1 group but did not reach statistical significance. Retinal thicknesses in the central area and in the vertical outer areas were higher in the DM1 group. Differences were found in the IRL with no changes in the outer ones. Long-term DM1 patients with no DR maintained visual function, with a decrease in VA with 1.25% ETDRS contrast. Macular thickness measurements were higher using Spectralis SD-OCT than DRI Triton SS-OCT, and DM1 patients had a decrease in IRL thickness, especially in the GCL at the parafoveal level, generating thinning of the RNFL in the peripheral areas. There were no differences in outer retinal layer (ORL) thickness.
000151018 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B08-7R$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI20-00740$$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-Oftared-RD16-0008
000151018 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000151018 590__ $$a4.997$$b2021
000151018 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000151018 592__ $$a1.005$$b2021
000151018 593__ $$aMultidisciplinary$$c2021$$dQ1
000151018 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000151018 700__ $$0(orcid)0000-0002-5621-1937$$aSanchez-Cano, Ana$$uUniversidad de Zaragoza
000151018 700__ $$0(orcid)0000-0002-9261-0302$$aPerdices, Lorena
000151018 700__ $$0(orcid)0000-0002-2987-6351$$aAcha, Javier$$uUniversidad de Zaragoza
000151018 700__ $$aLopez-Alaminos, Elena María
000151018 700__ $$0(orcid)0000-0003-0349-9997$$aPinilla, Isabel$$uUniversidad de Zaragoza
000151018 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000151018 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000151018 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000151018 773__ $$g11 (2021), 10427 [10 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000151018 8564_ $$s1466261$$uhttps://zaguan.unizar.es/record/151018/files/texto_completo.pdf$$yVersión publicada
000151018 8564_ $$s2423138$$uhttps://zaguan.unizar.es/record/151018/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000151018 909CO $$ooai:zaguan.unizar.es:151018$$particulos$$pdriver
000151018 951__ $$a2025-02-21-09:52:36
000151018 980__ $$aARTICLE