151053 20251017144633.0 doi 10.3390/genes13050865 sideral 129148 ART-2022-129148 eng Calvo, Ana Cristina Universidad de Zaragoza (orcid)0000-0001-5193-7782 Lessons to Learn from the Gut Microbiota: A Focus on Amyotrophic Lateral Sclerosis 2022 Access copy available to the general public Unrestricted The gut microbiota is able to modulate the development and homeostasis of the central nervous system (CNS) through the immune, circulatory, and neuronal systems. In turn, the CNS influences the gut microbiota through stress responses and at the level of the endocrine system. This bidirectional communication forms the “gut microbiota–brain axis” and has been postulated to play a role in the etiopathology of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Numerous studies in animal models of ALS and in patients have highlighted the close communication between the immune system and the gut microbiota and, therefore, it is possible that alterations in the gut microbiota may have a direct impact on neuronal function and survival in ALS patients. Consequently, if the gut dysbiosis does indeed play a role in ALS-related neurodegeneration, nutritional immunomodulatory interventions based on probiotics, prebiotics, and/or postbiotics could emerge as innovative therapeutic strategies. This review aimed to shed light on the impact of the gut microbiota in ALS disease and on the use of potential nutritional interventions based on different types of biotics to ameliorate ALS symptoms. info:eu-repo/grantAgreement/ES/ISCIII/FEDER/PI21-00372 info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.5 2022 GENETICS & HEREDITY 66 / 171 = 0.386 2022 Q2 T2 0.924 2022 Genetics (clinical) 2022 Q2 Genetics 2022 Q2 5.1 2022 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Valledor-Martín, Inés Moreno-Martínez, Laura Universidad de Zaragoza (orcid)0000-0002-7277-4318 Toivonen, Janne Markus Universidad de Zaragoza (orcid)0000-0002-7243-1737 Osta, Rosario Universidad de Zaragoza (orcid)0000-0001-5687-6704 1001 420 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Genética 1012 315 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Farmacología 13, 5 (2022), 865 [13 pp.] Genes (Basel) Genes 2073-4425 308784 http://zaguan.unizar.es/record/151053/files/texto_completo.pdf Versión publicada 2636624 http://zaguan.unizar.es/record/151053/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:151053 articulos driver 2025-10-17-14:27:33 ARTICLE